Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature

Ali Dirani,1 Alexandre Matet,1 Talal Beydoun,2 Irmela Mantel,1 Francine Behar-Cohen1–3 1Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland; 2Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique &nda...

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Autores principales:	Dirani A, Matet A, Beydoun T, Mantel I, Behar-Cohen F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/77491373418a4651855f29ec3ac72a7f
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spelling	oai:doaj.org-article:77491373418a4651855f29ec3ac72a7f2021-12-02T06:07:53ZResolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature1177-5483https://doaj.org/article/77491373418a4651855f29ec3ac72a7f2014-05-01T00:00:00Zhttp://www.dovepress.com/resolution-of-foveal-detachment-in-dome-shaped-macula-after-treatment--a16907https://doaj.org/toc/1177-5483 Ali Dirani,1 Alexandre Matet,1 Talal Beydoun,2 Irmela Mantel,1 Francine Behar-Cohen1–3 1Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland; 2Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 3Inserm UMRS872, Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Paris, France Abstract: Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist. Keywords: serous foveal detachment, mineralocorticoid receptor antagonist, dome-shaped macula, treatmentDirani AMatet ABeydoun TMantel IBehar-Cohen FDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 999-1002 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Dirani A Matet A Beydoun T Mantel I Behar-Cohen F Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
description	Ali Dirani,1 Alexandre Matet,1 Talal Beydoun,2 Irmela Mantel,1 Francine Behar-Cohen1–3 1Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland; 2Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 3Inserm UMRS872, Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Paris, France Abstract: Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist. Keywords: serous foveal detachment, mineralocorticoid receptor antagonist, dome-shaped macula, treatment
format	article
author	Dirani A Matet A Beydoun T Mantel I Behar-Cohen F
author_facet	Dirani A Matet A Beydoun T Mantel I Behar-Cohen F
author_sort	Dirani A
title	Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_short	Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_full	Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_fullStr	Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_full_unstemmed	Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_sort	resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/77491373418a4651855f29ec3ac72a7f
work_keys_str_mv	AT dirania resolutionoffovealdetachmentindomeshapedmaculaaftertreatmentbyspironolactonereportoftwocasesandminireviewoftheliterature AT mateta resolutionoffovealdetachmentindomeshapedmaculaaftertreatmentbyspironolactonereportoftwocasesandminireviewoftheliterature AT beydount resolutionoffovealdetachmentindomeshapedmaculaaftertreatmentbyspironolactonereportoftwocasesandminireviewoftheliterature AT manteli resolutionoffovealdetachmentindomeshapedmaculaaftertreatmentbyspironolactonereportoftwocasesandminireviewoftheliterature AT beharcohenf resolutionoffovealdetachmentindomeshapedmaculaaftertreatmentbyspironolactonereportoftwocasesandminireviewoftheliterature
_version_	1718400058326515712

Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature

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