Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia

Abstract Psychophysiological insomnia (PI) includes arousal to sleep-related stimuli (SS), which can be treated by cognitive behavioral therapy for insomnia (CBT-I). The present study was an exploratory, prospective intervention study that aimed to explore brain response to visual SS in PI before an...

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Autores principales:	Seog Ju Kim, Yu Jin Lee, Nambeom Kim, Soohyun Kim, Jae-Won Choi, Juhyun Park, Ah Reum Gwak, Chang-Ki Kang, Seung-Gul Kang, Do-Un Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/774c164229ea434bb1f58c96f5e3f415
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spelling	oai:doaj.org-article:774c164229ea434bb1f58c96f5e3f4152021-12-02T15:05:24ZExploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia10.1038/s41598-017-13065-02045-2322https://doaj.org/article/774c164229ea434bb1f58c96f5e3f4152017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13065-0https://doaj.org/toc/2045-2322Abstract Psychophysiological insomnia (PI) includes arousal to sleep-related stimuli (SS), which can be treated by cognitive behavioral therapy for insomnia (CBT-I). The present study was an exploratory, prospective intervention study that aimed to explore brain response to visual SS in PI before and after CBT-I. Blood oxygen level dependent (BOLD) signal differences in response to SS and neutral stimuli (NS) were compared between 14 drug-free PI patients and 18 good sleepers (GS) using functional magnetic resonance imaging (fMRI). BOLD changes after CBT-I in patients were also examined. PI patients showed higher BOLD activation to SS in the precentral, prefrontal, fusiform, and posterior cingulate cortices before CBT-I. The increased responses to SS were reduced after CBT-I. The increased response to SS in the precentral cortex was associated with longer wake time after sleep onset (WASO), and its reduction after CBT-I was associated with improvements in WASO. Clinical improvements after CBT-I were correlated with BOLD reduction in the right insula and left paracentral cortex in response to SS. PI showed hyper-responses to SS in the precentral cortex, prefrontal cortex, and default mode network and these brain hyper-responses were normalized after CBT-I. CBT-I may exert its treatment effects on PI by reducing hyper-responses to SS in the precentral cortex and insula.Seog Ju KimYu Jin LeeNambeom KimSoohyun KimJae-Won ChoiJuhyun ParkAh Reum GwakChang-Ki KangSeung-Gul KangDo-Un JeongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seog Ju Kim Yu Jin Lee Nambeom Kim Soohyun Kim Jae-Won Choi Juhyun Park Ah Reum Gwak Chang-Ki Kang Seung-Gul Kang Do-Un Jeong Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
description	Abstract Psychophysiological insomnia (PI) includes arousal to sleep-related stimuli (SS), which can be treated by cognitive behavioral therapy for insomnia (CBT-I). The present study was an exploratory, prospective intervention study that aimed to explore brain response to visual SS in PI before and after CBT-I. Blood oxygen level dependent (BOLD) signal differences in response to SS and neutral stimuli (NS) were compared between 14 drug-free PI patients and 18 good sleepers (GS) using functional magnetic resonance imaging (fMRI). BOLD changes after CBT-I in patients were also examined. PI patients showed higher BOLD activation to SS in the precentral, prefrontal, fusiform, and posterior cingulate cortices before CBT-I. The increased responses to SS were reduced after CBT-I. The increased response to SS in the precentral cortex was associated with longer wake time after sleep onset (WASO), and its reduction after CBT-I was associated with improvements in WASO. Clinical improvements after CBT-I were correlated with BOLD reduction in the right insula and left paracentral cortex in response to SS. PI showed hyper-responses to SS in the precentral cortex, prefrontal cortex, and default mode network and these brain hyper-responses were normalized after CBT-I. CBT-I may exert its treatment effects on PI by reducing hyper-responses to SS in the precentral cortex and insula.
format	article
author	Seog Ju Kim Yu Jin Lee Nambeom Kim Soohyun Kim Jae-Won Choi Juhyun Park Ah Reum Gwak Chang-Ki Kang Seung-Gul Kang Do-Un Jeong
author_facet	Seog Ju Kim Yu Jin Lee Nambeom Kim Soohyun Kim Jae-Won Choi Juhyun Park Ah Reum Gwak Chang-Ki Kang Seung-Gul Kang Do-Un Jeong
author_sort	Seog Ju Kim
title	Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
title_short	Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
title_full	Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
title_fullStr	Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
title_full_unstemmed	Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
title_sort	exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/774c164229ea434bb1f58c96f5e3f415
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Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia

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