Impact of semaphorin expression on prognostic characteristics in breast cancer

Ramesh Butti, Totakura VS Kumar, Ramakrishna Nimma, Gopal C Kundu Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Savitribai Phule Pune University, Pune, India Abstract: Breast cancer is one of the major causes of cancer-related deaths among wom...

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Autores principales:	Butti R, Kumar TVS, Nimma R, Kundu GC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Breast cancer Tumor microenvironment Semaphorins Plexins Neuropilins Cancer stem-like cells Prognostic factor Angiogenesis Metastasis Epithelial to mesenchymal transition Vascular endothelial growth factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/774ce3e7711646b5abfba04115f9b7af
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spelling	oai:doaj.org-article:774ce3e7711646b5abfba04115f9b7af2021-12-02T05:26:55ZImpact of semaphorin expression on prognostic characteristics in breast cancer1179-1314https://doaj.org/article/774ce3e7711646b5abfba04115f9b7af2018-05-01T00:00:00Zhttps://www.dovepress.com/impact-of-semaphorin-expression-on-prognostic-characteristics-in-breas-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Ramesh Butti, Totakura VS Kumar, Ramakrishna Nimma, Gopal C Kundu Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Savitribai Phule Pune University, Pune, India Abstract: Breast cancer is one of the major causes of cancer-related deaths among women worldwide. Aberrant regulation of various growth factors, cytokines, and other proteins and their receptors in cancer cells drives the activation of various oncogenic signaling pathways that lead to cancer progression. Semaphorins are a class of proteins which are differentially expressed in various types of cancer including breast cancer. Earlier, these proteins were known to have a major function in the nerve cell adhesion, migration, and development of the central nervous system. However, their role in the regulation of several aspects of tumor progression has eventually emerged. There are over 30 genes encoding the semaphorins, which are divided into eight subclasses. It has been reported that some members of semaphorin classes are antiangiogenic and antimetastatic in nature, whereas others act as proangiogenic and prometastatic genes. Because of their differential expression and role in angiogenesis and metastasis, semaphorins emerged as one of the important prognostic factors for appraising breast cancer progression. Keywords: breast cancer, tumor microenvironment, semaphorins, plexins, neuropilins, cancer stem-like cells, prognostic factor, angiogenesis, metastasis, epithelial to mesenchymal transition, vascular endothelial growth factorButti RKumar TVSNimma RKundu GCDove Medical PressarticleBreast cancerTumor microenvironmentSemaphorinsPlexinsNeuropilinsCancer stem-like cellsPrognostic factorAngiogenesisMetastasisEpithelial to mesenchymal transitionVascular endothelial growth factorNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 10, Pp 79-88 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer Tumor microenvironment Semaphorins Plexins Neuropilins Cancer stem-like cells Prognostic factor Angiogenesis Metastasis Epithelial to mesenchymal transition Vascular endothelial growth factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast cancer Tumor microenvironment Semaphorins Plexins Neuropilins Cancer stem-like cells Prognostic factor Angiogenesis Metastasis Epithelial to mesenchymal transition Vascular endothelial growth factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Butti R Kumar TVS Nimma R Kundu GC Impact of semaphorin expression on prognostic characteristics in breast cancer
description	Ramesh Butti, Totakura VS Kumar, Ramakrishna Nimma, Gopal C Kundu Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Savitribai Phule Pune University, Pune, India Abstract: Breast cancer is one of the major causes of cancer-related deaths among women worldwide. Aberrant regulation of various growth factors, cytokines, and other proteins and their receptors in cancer cells drives the activation of various oncogenic signaling pathways that lead to cancer progression. Semaphorins are a class of proteins which are differentially expressed in various types of cancer including breast cancer. Earlier, these proteins were known to have a major function in the nerve cell adhesion, migration, and development of the central nervous system. However, their role in the regulation of several aspects of tumor progression has eventually emerged. There are over 30 genes encoding the semaphorins, which are divided into eight subclasses. It has been reported that some members of semaphorin classes are antiangiogenic and antimetastatic in nature, whereas others act as proangiogenic and prometastatic genes. Because of their differential expression and role in angiogenesis and metastasis, semaphorins emerged as one of the important prognostic factors for appraising breast cancer progression. Keywords: breast cancer, tumor microenvironment, semaphorins, plexins, neuropilins, cancer stem-like cells, prognostic factor, angiogenesis, metastasis, epithelial to mesenchymal transition, vascular endothelial growth factor
format	article
author	Butti R Kumar TVS Nimma R Kundu GC
author_facet	Butti R Kumar TVS Nimma R Kundu GC
author_sort	Butti R
title	Impact of semaphorin expression on prognostic characteristics in breast cancer
title_short	Impact of semaphorin expression on prognostic characteristics in breast cancer
title_full	Impact of semaphorin expression on prognostic characteristics in breast cancer
title_fullStr	Impact of semaphorin expression on prognostic characteristics in breast cancer
title_full_unstemmed	Impact of semaphorin expression on prognostic characteristics in breast cancer
title_sort	impact of semaphorin expression on prognostic characteristics in breast cancer
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/774ce3e7711646b5abfba04115f9b7af
work_keys_str_mv	AT buttir impactofsemaphorinexpressiononprognosticcharacteristicsinbreastcancer AT kumartvs impactofsemaphorinexpressiononprognosticcharacteristicsinbreastcancer AT nimmar impactofsemaphorinexpressiononprognosticcharacteristicsinbreastcancer AT kundugc impactofsemaphorinexpressiononprognosticcharacteristicsinbreastcancer
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Impact of semaphorin expression on prognostic characteristics in breast cancer

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