Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish

Abstract Microplastics have become pervasive environmental pollutants in both freshwater and marine ecosystems. The presence of microplastics have been recorded in the tissues of many wild fish species, and laboratory studies have demonstrated that microplastics can exert adverse health effects. To...

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Autores principales:	Giacomo Limonta, Annalaura Mancia, Assja Benkhalqui, Cristiano Bertolucci, Luigi Abelli, Maria Cristina Fossi, Cristina Panti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77525d756e5544f6b1624d1e3c1f040b
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spelling	oai:doaj.org-article:77525d756e5544f6b1624d1e3c1f040b2021-12-02T15:09:47ZMicroplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish10.1038/s41598-019-52292-52045-2322https://doaj.org/article/77525d756e5544f6b1624d1e3c1f040b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-52292-5https://doaj.org/toc/2045-2322Abstract Microplastics have become pervasive environmental pollutants in both freshwater and marine ecosystems. The presence of microplastics have been recorded in the tissues of many wild fish species, and laboratory studies have demonstrated that microplastics can exert adverse health effects. To further investigate the biological mechanisms underlying microplastics toxicity we applied an integrated approach, analyzing the effects of microplastics at transcriptomic, histological and behavioral level. Adult zebrafish have been exposed to two concentrations of high-density polyethylene and polystyrene microplastics for twenty days. Transcriptomic results indicate alterations in the expression of immune system genes and the down-regulation of genes correlated with epithelium integrity and lipid metabolism. The transcriptomic findings are supported by tissue alterations and higher occurrence of neutrophils observed in gills and intestinal epithelium. Even the daily rhythm of activity of zebrafish appears to be affected, although the regular pattern of activity is recovered over time. Considering the transcriptomic and histological findings reported, we hypothesize that the effects on mucosal epithelium integrity and immune response could potentially reduce the organism defense against pathogens, and lead to a different utilization of energy stores.Giacomo LimontaAnnalaura ManciaAssja BenkhalquiCristiano BertolucciLuigi AbelliMaria Cristina FossiCristina PantiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giacomo Limonta Annalaura Mancia Assja Benkhalqui Cristiano Bertolucci Luigi Abelli Maria Cristina Fossi Cristina Panti Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
description	Abstract Microplastics have become pervasive environmental pollutants in both freshwater and marine ecosystems. The presence of microplastics have been recorded in the tissues of many wild fish species, and laboratory studies have demonstrated that microplastics can exert adverse health effects. To further investigate the biological mechanisms underlying microplastics toxicity we applied an integrated approach, analyzing the effects of microplastics at transcriptomic, histological and behavioral level. Adult zebrafish have been exposed to two concentrations of high-density polyethylene and polystyrene microplastics for twenty days. Transcriptomic results indicate alterations in the expression of immune system genes and the down-regulation of genes correlated with epithelium integrity and lipid metabolism. The transcriptomic findings are supported by tissue alterations and higher occurrence of neutrophils observed in gills and intestinal epithelium. Even the daily rhythm of activity of zebrafish appears to be affected, although the regular pattern of activity is recovered over time. Considering the transcriptomic and histological findings reported, we hypothesize that the effects on mucosal epithelium integrity and immune response could potentially reduce the organism defense against pathogens, and lead to a different utilization of energy stores.
format	article
author	Giacomo Limonta Annalaura Mancia Assja Benkhalqui Cristiano Bertolucci Luigi Abelli Maria Cristina Fossi Cristina Panti
author_facet	Giacomo Limonta Annalaura Mancia Assja Benkhalqui Cristiano Bertolucci Luigi Abelli Maria Cristina Fossi Cristina Panti
author_sort	Giacomo Limonta
title	Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
title_short	Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
title_full	Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
title_fullStr	Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
title_full_unstemmed	Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
title_sort	microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/77525d756e5544f6b1624d1e3c1f040b
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Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish

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