Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children

Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children

Abstract Now there is no clinical scale for early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study is to identify indicators and develop an early predictive scale for RMPP in hospitalized children. First we conducted a retrospective cohort study of children with...

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Autores principales: Ying Bi, Yifan Zhu, Xiao Ma, Jiejing Xu, Yun Guo, Tianyu Huang, Siqing Zhang, Xin Wang, Deyu Zhao, Feng Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/775410b9baee46babf2bd3af390610c5
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spelling oai:doaj.org-article:775410b9baee46babf2bd3af390610c52021-12-02T11:45:03ZDevelopment of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children10.1038/s41598-021-86086-52045-2322https://doaj.org/article/775410b9baee46babf2bd3af390610c52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86086-5https://doaj.org/toc/2045-2322Abstract Now there is no clinical scale for early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study is to identify indicators and develop an early predictive scale for RMPP in hospitalized children. First we conducted a retrospective cohort study of children with M. pneumoniae pneumonia admitted to Children’s Hospital of Nanjing Medical University, China in 2016. Children were divided into two groups, according to whether their pneumonia were refractory and the results were used to develop an early predictive scale. Second we conducted a prospective study to validate the predictive scale for RMPP in children in 2018. 618 children were included in the retrospective study, of which 73 with RMPP. Six prognostic indicators were identified and included in the prognostic assessment scale. The sensitivity of the prognostic assessment scale was 74.0% (54/73), and the specificity was 88.3% (481/545) in the retrospective study. 944 children were included in the prospective cohort, including 92 with RMPP, the sensitivity of the prognostic assessment scale was 78.3% (72/92) and the specificity was 86.2% (734/852). The prognostic assessment scale for RMPP has high diagnostic accuracy and is suitable for use in standard clinical practice.Ying BiYifan ZhuXiao MaJiejing XuYun GuoTianyu HuangSiqing ZhangXin WangDeyu ZhaoFeng LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ying Bi
Yifan Zhu
Xiao Ma
Jiejing Xu
Yun Guo
Tianyu Huang
Siqing Zhang
Xin Wang
Deyu Zhao
Feng Liu
Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children
description Abstract Now there is no clinical scale for early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study is to identify indicators and develop an early predictive scale for RMPP in hospitalized children. First we conducted a retrospective cohort study of children with M. pneumoniae pneumonia admitted to Children’s Hospital of Nanjing Medical University, China in 2016. Children were divided into two groups, according to whether their pneumonia were refractory and the results were used to develop an early predictive scale. Second we conducted a prospective study to validate the predictive scale for RMPP in children in 2018. 618 children were included in the retrospective study, of which 73 with RMPP. Six prognostic indicators were identified and included in the prognostic assessment scale. The sensitivity of the prognostic assessment scale was 74.0% (54/73), and the specificity was 88.3% (481/545) in the retrospective study. 944 children were included in the prospective cohort, including 92 with RMPP, the sensitivity of the prognostic assessment scale was 78.3% (72/92) and the specificity was 86.2% (734/852). The prognostic assessment scale for RMPP has high diagnostic accuracy and is suitable for use in standard clinical practice.
format article
author Ying Bi
Yifan Zhu
Xiao Ma
Jiejing Xu
Yun Guo
Tianyu Huang
Siqing Zhang
Xin Wang
Deyu Zhao
Feng Liu
author_facet Ying Bi
Yifan Zhu
Xiao Ma
Jiejing Xu
Yun Guo
Tianyu Huang
Siqing Zhang
Xin Wang
Deyu Zhao
Feng Liu
author_sort Ying Bi
title Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children
title_short Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children
title_full Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children
title_fullStr Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children
title_full_unstemmed Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children
title_sort development of a scale for early prediction of refractory mycoplasma pneumoniae pneumonia in hospitalized children
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/775410b9baee46babf2bd3af390610c5
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