Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort
Genetics: heredity does not explain HER2 expression A large gene-finding study failed to identify any hereditary factors linked to HER2 expression among women with breast cancer. A team in France led by Xavier Pivot from the University Hospital Center of Besançon, France, analyzed more than 500,000...
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Nature Portfolio
2017
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oai:doaj.org-article:7754f161934e43488fc3e344469643632021-12-02T12:30:31ZConstitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort10.1038/s41523-017-0005-y2374-4677https://doaj.org/article/7754f161934e43488fc3e344469643632017-02-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0005-yhttps://doaj.org/toc/2374-4677Genetics: heredity does not explain HER2 expression A large gene-finding study failed to identify any hereditary factors linked to HER2 expression among women with breast cancer. A team in France led by Xavier Pivot from the University Hospital Center of Besançon, France, analyzed more than 500,000 single DNA letters from a cohort of 8703 patients with breast cancer, 3230 of whom had tumors with high expression of human epidermal growth factor receptor 2 (HER2) and are thus treated with for anti-HER2 targeted therapies. The researchers searched for DNA variants associated with HER2 status, but none reached the threshold for statistical significance. The findings reveal a high level of genetic diversity in women with HER2-positive breast cancer and suggest that HER2 amplification may have more to do with the intrinsic nature of the tumor than with the genetics of the patient.Xavier PivotGilles RomieuPierre FumoleauMaria RiosHervé BonnefoiThomas BachelotPatrick SouliéChristelle JouannaudHugues BourgeoisThierry PetitIsabelle TennevetDavid AssoulineMarie-Christine MathieuJean-Philippe JacquinSandrine Lavau-DenesAriane Darut-JouveJean-Marc FerreroCarole TarpinChristelle LévyValérie DelecroixVéronique Trillet-LenoirOana CojocarasuJérôme MeunierJean-Yves PiergaCécile AgostiniPierre KerbratCéline Faure-MercierHélène BlanchéMourad SahbatouAnne BolandDelphine BacqCéline BesseFabien CalvoAlexia RenaudJean-François DeleuzeIris PauportéGilles ThomasDavid G. CoxNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-5 (2017) |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xavier Pivot Gilles Romieu Pierre Fumoleau Maria Rios Hervé Bonnefoi Thomas Bachelot Patrick Soulié Christelle Jouannaud Hugues Bourgeois Thierry Petit Isabelle Tennevet David Assouline Marie-Christine Mathieu Jean-Philippe Jacquin Sandrine Lavau-Denes Ariane Darut-Jouve Jean-Marc Ferrero Carole Tarpin Christelle Lévy Valérie Delecroix Véronique Trillet-Lenoir Oana Cojocarasu Jérôme Meunier Jean-Yves Pierga Cécile Agostini Pierre Kerbrat Céline Faure-Mercier Hélène Blanché Mourad Sahbatou Anne Boland Delphine Bacq Céline Besse Fabien Calvo Alexia Renaud Jean-François Deleuze Iris Pauporté Gilles Thomas David G. Cox Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort |
| description |
Genetics: heredity does not explain HER2 expression A large gene-finding study failed to identify any hereditary factors linked to HER2 expression among women with breast cancer. A team in France led by Xavier Pivot from the University Hospital Center of Besançon, France, analyzed more than 500,000 single DNA letters from a cohort of 8703 patients with breast cancer, 3230 of whom had tumors with high expression of human epidermal growth factor receptor 2 (HER2) and are thus treated with for anti-HER2 targeted therapies. The researchers searched for DNA variants associated with HER2 status, but none reached the threshold for statistical significance. The findings reveal a high level of genetic diversity in women with HER2-positive breast cancer and suggest that HER2 amplification may have more to do with the intrinsic nature of the tumor than with the genetics of the patient. |
| format |
article |
| author |
Xavier Pivot Gilles Romieu Pierre Fumoleau Maria Rios Hervé Bonnefoi Thomas Bachelot Patrick Soulié Christelle Jouannaud Hugues Bourgeois Thierry Petit Isabelle Tennevet David Assouline Marie-Christine Mathieu Jean-Philippe Jacquin Sandrine Lavau-Denes Ariane Darut-Jouve Jean-Marc Ferrero Carole Tarpin Christelle Lévy Valérie Delecroix Véronique Trillet-Lenoir Oana Cojocarasu Jérôme Meunier Jean-Yves Pierga Cécile Agostini Pierre Kerbrat Céline Faure-Mercier Hélène Blanché Mourad Sahbatou Anne Boland Delphine Bacq Céline Besse Fabien Calvo Alexia Renaud Jean-François Deleuze Iris Pauporté Gilles Thomas David G. Cox |
| author_facet |
Xavier Pivot Gilles Romieu Pierre Fumoleau Maria Rios Hervé Bonnefoi Thomas Bachelot Patrick Soulié Christelle Jouannaud Hugues Bourgeois Thierry Petit Isabelle Tennevet David Assouline Marie-Christine Mathieu Jean-Philippe Jacquin Sandrine Lavau-Denes Ariane Darut-Jouve Jean-Marc Ferrero Carole Tarpin Christelle Lévy Valérie Delecroix Véronique Trillet-Lenoir Oana Cojocarasu Jérôme Meunier Jean-Yves Pierga Cécile Agostini Pierre Kerbrat Céline Faure-Mercier Hélène Blanché Mourad Sahbatou Anne Boland Delphine Bacq Céline Besse Fabien Calvo Alexia Renaud Jean-François Deleuze Iris Pauporté Gilles Thomas David G. Cox |
| author_sort |
Xavier Pivot |
| title |
Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort |
| title_short |
Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort |
| title_full |
Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort |
| title_fullStr |
Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort |
| title_full_unstemmed |
Constitutional variants are not associated with HER2-positive breast cancer: results from the SIGNAL/PHARE clinical cohort |
| title_sort |
constitutional variants are not associated with her2-positive breast cancer: results from the signal/phare clinical cohort |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/7754f161934e43488fc3e34446964363 |
| work_keys_str_mv |
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