Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival.

Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival.

<h4>Background</h4>Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may promote the development of castration-resistant prostate cancer (CRPC). The expression of AR-Vs in the clinically most important metastatic site, the bone, has, however,...

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Autores principales: Emma Hörnberg, Erik Bovinder Ylitalo, Sead Crnalic, Henrik Antti, Pär Stattin, Anders Widmark, Anders Bergh, Pernilla Wikström
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/77576da190d54660a4133de279e53412
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