ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.
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Nature Portfolio
2019
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oai:doaj.org-article:7757796c1cc14b99b37e09335d62edfc2021-12-02T15:35:31ZZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response10.1038/s41467-019-10967-72041-1723https://doaj.org/article/7757796c1cc14b99b37e09335d62edfc2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10967-7https://doaj.org/toc/2041-1723Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.Adebowale A. AdeyemoNorann A. ZaghloulGuanjie ChenAyo P. DoumateyCarmen C. LeitchTimothy L. HostelleyJessica E. NesmithJie ZhouAmy R. BentleyDaniel ShrinerOlufemi FasanmadeGodfrey OkaforBenjamin EghanKofi Agyenim-BoatengSettara ChandrasekharappaJokotade AdeleyeWilliam BalogunSamuel OwusuAlbert AmoahJoseph AcheampongThomas JohnsonJohnnie OliClement AdebamowoSouth Africa Zulu Type 2 Diabetes Case-Control StudyFrancis CollinsGeorgia DunstonCharles N. RotimiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Adebowale A. Adeyemo Norann A. Zaghloul Guanjie Chen Ayo P. Doumatey Carmen C. Leitch Timothy L. Hostelley Jessica E. Nesmith Jie Zhou Amy R. Bentley Daniel Shriner Olufemi Fasanmade Godfrey Okafor Benjamin Eghan Kofi Agyenim-Boateng Settara Chandrasekharappa Jokotade Adeleye William Balogun Samuel Owusu Albert Amoah Joseph Acheampong Thomas Johnson Johnnie Oli Clement Adebamowo South Africa Zulu Type 2 Diabetes Case-Control Study Francis Collins Georgia Dunston Charles N. Rotimi ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| description |
Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population. |
| format |
article |
| author |
Adebowale A. Adeyemo Norann A. Zaghloul Guanjie Chen Ayo P. Doumatey Carmen C. Leitch Timothy L. Hostelley Jessica E. Nesmith Jie Zhou Amy R. Bentley Daniel Shriner Olufemi Fasanmade Godfrey Okafor Benjamin Eghan Kofi Agyenim-Boateng Settara Chandrasekharappa Jokotade Adeleye William Balogun Samuel Owusu Albert Amoah Joseph Acheampong Thomas Johnson Johnnie Oli Clement Adebamowo South Africa Zulu Type 2 Diabetes Case-Control Study Francis Collins Georgia Dunston Charles N. Rotimi |
| author_facet |
Adebowale A. Adeyemo Norann A. Zaghloul Guanjie Chen Ayo P. Doumatey Carmen C. Leitch Timothy L. Hostelley Jessica E. Nesmith Jie Zhou Amy R. Bentley Daniel Shriner Olufemi Fasanmade Godfrey Okafor Benjamin Eghan Kofi Agyenim-Boateng Settara Chandrasekharappa Jokotade Adeleye William Balogun Samuel Owusu Albert Amoah Joseph Acheampong Thomas Johnson Johnnie Oli Clement Adebamowo South Africa Zulu Type 2 Diabetes Case-Control Study Francis Collins Georgia Dunston Charles N. Rotimi |
| author_sort |
Adebowale A. Adeyemo |
| title |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_short |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_full |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_fullStr |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_full_unstemmed |
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| title_sort |
zranb3 is an african-specific type 2 diabetes locus associated with beta-cell mass and insulin response |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7757796c1cc14b99b37e09335d62edfc |
| work_keys_str_mv |
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