Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis

Abstract Recent studies have indicated that there are functional genomic signals that can be detected in blood years before cancer diagnosis. This study aimed to assess gene expression in prospective blood samples from the Norwegian Women and Cancer cohort focusing on time to lung cancer diagnosis a...

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Autores principales:	Therese H. Nøst, Marit Holden, Tom Dønnem, Hege Bøvelstad, Charlotta Rylander, Eiliv Lund, Torkjel M. Sandanger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/775928b8780d4dd1b88f54e25380a25a
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spelling	oai:doaj.org-article:775928b8780d4dd1b88f54e25380a25a2021-12-02T14:23:14ZTranscriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis10.1038/s41598-021-86879-82045-2322https://doaj.org/article/775928b8780d4dd1b88f54e25380a25a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86879-8https://doaj.org/toc/2045-2322Abstract Recent studies have indicated that there are functional genomic signals that can be detected in blood years before cancer diagnosis. This study aimed to assess gene expression in prospective blood samples from the Norwegian Women and Cancer cohort focusing on time to lung cancer diagnosis and metastatic cancer using a nested case–control design. We employed several approaches to statistically analyze the data and the methods indicated that the case–control differences were subtle but most distinguishable in metastatic case–control pairs in the period 0–3 years prior to diagnosis. The genes of interest along with estimated blood cell populations could indicate disruption of immunological processes in blood. The genes identified from approaches focusing on alterations with time to diagnosis were distinct from those focusing on the case–control differences. Our results support that explorative analyses of prospective blood samples could indicate circulating signals of disease-related processes.Therese H. NøstMarit HoldenTom DønnemHege BøvelstadCharlotta RylanderEiliv LundTorkjel M. SandangerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Therese H. Nøst Marit Holden Tom Dønnem Hege Bøvelstad Charlotta Rylander Eiliv Lund Torkjel M. Sandanger Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
description	Abstract Recent studies have indicated that there are functional genomic signals that can be detected in blood years before cancer diagnosis. This study aimed to assess gene expression in prospective blood samples from the Norwegian Women and Cancer cohort focusing on time to lung cancer diagnosis and metastatic cancer using a nested case–control design. We employed several approaches to statistically analyze the data and the methods indicated that the case–control differences were subtle but most distinguishable in metastatic case–control pairs in the period 0–3 years prior to diagnosis. The genes of interest along with estimated blood cell populations could indicate disruption of immunological processes in blood. The genes identified from approaches focusing on alterations with time to diagnosis were distinct from those focusing on the case–control differences. Our results support that explorative analyses of prospective blood samples could indicate circulating signals of disease-related processes.
format	article
author	Therese H. Nøst Marit Holden Tom Dønnem Hege Bøvelstad Charlotta Rylander Eiliv Lund Torkjel M. Sandanger
author_facet	Therese H. Nøst Marit Holden Tom Dønnem Hege Bøvelstad Charlotta Rylander Eiliv Lund Torkjel M. Sandanger
author_sort	Therese H. Nøst
title	Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
title_short	Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
title_full	Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
title_fullStr	Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
title_full_unstemmed	Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
title_sort	transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/775928b8780d4dd1b88f54e25380a25a
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Transcriptomic signals in blood prior to lung cancer focusing on time to diagnosis and metastasis

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