Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study

Abstract The association between bladder antimuscarinic use and dementia development is unclear. We used data from the Taiwan National Health Insurance Research Database to determine the association between the exposure dose and duration of bladder antimuscarinics and the subsequent dementia risk. W...

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Autores principales:	Tomor Harnod, Yu-Cih Yang, Lu-Ting Chiu, Jen-Hung Wang, Shinn-Zong Lin, Dah-Ching Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/775a7b8404e841fab4e5a57427c7b5a6
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spelling	oai:doaj.org-article:775a7b8404e841fab4e5a57427c7b5a62021-12-02T13:30:11ZUse of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study10.1038/s41598-021-84229-22045-2322https://doaj.org/article/775a7b8404e841fab4e5a57427c7b5a62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84229-2https://doaj.org/toc/2045-2322Abstract The association between bladder antimuscarinic use and dementia development is unclear. We used data from the Taiwan National Health Insurance Research Database to determine the association between the exposure dose and duration of bladder antimuscarinics and the subsequent dementia risk. We enrolled participants aged 55 years or more and defined a dementia cohort (International Classification of Diseases, Ninth Revision, Clinical Modification codes 290, 294.1, and 331.0). We used a propensity score matching method, and randomly enrolled two controls without dementia. We evaluated dementia risk with respect to the exposure dose and duration of treatment with seven bladder antimuscarinics (oxybutynin, propiverine, tolterodine, solifenacin, trospium, darifenacin, and fesoterodine) used for at least 1 year before the index date, after adjusting for age, sex, comorbidities, and medications. The dementia risk was 2.46-fold (95% confidence interval: 2.22–2.73) higher in Taiwanese patients who used bladder antimuscarinics for ≥ 1 year than in those who were not exposed to this treatment. The risk proportionally increased with increasing doses of antimuscarinics for less than 4 years. Taiwanese patients aged 55 years or more on bladder antimuscarinics exhibited a higher risk of dementia. Additional studies in other countries are required to determine whether this result is valid worldwide.Tomor HarnodYu-Cih YangLu-Ting ChiuJen-Hung WangShinn-Zong LinDah-Ching DingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomor Harnod Yu-Cih Yang Lu-Ting Chiu Jen-Hung Wang Shinn-Zong Lin Dah-Ching Ding Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
description	Abstract The association between bladder antimuscarinic use and dementia development is unclear. We used data from the Taiwan National Health Insurance Research Database to determine the association between the exposure dose and duration of bladder antimuscarinics and the subsequent dementia risk. We enrolled participants aged 55 years or more and defined a dementia cohort (International Classification of Diseases, Ninth Revision, Clinical Modification codes 290, 294.1, and 331.0). We used a propensity score matching method, and randomly enrolled two controls without dementia. We evaluated dementia risk with respect to the exposure dose and duration of treatment with seven bladder antimuscarinics (oxybutynin, propiverine, tolterodine, solifenacin, trospium, darifenacin, and fesoterodine) used for at least 1 year before the index date, after adjusting for age, sex, comorbidities, and medications. The dementia risk was 2.46-fold (95% confidence interval: 2.22–2.73) higher in Taiwanese patients who used bladder antimuscarinics for ≥ 1 year than in those who were not exposed to this treatment. The risk proportionally increased with increasing doses of antimuscarinics for less than 4 years. Taiwanese patients aged 55 years or more on bladder antimuscarinics exhibited a higher risk of dementia. Additional studies in other countries are required to determine whether this result is valid worldwide.
format	article
author	Tomor Harnod Yu-Cih Yang Lu-Ting Chiu Jen-Hung Wang Shinn-Zong Lin Dah-Ching Ding
author_facet	Tomor Harnod Yu-Cih Yang Lu-Ting Chiu Jen-Hung Wang Shinn-Zong Lin Dah-Ching Ding
author_sort	Tomor Harnod
title	Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
title_short	Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
title_full	Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
title_fullStr	Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
title_full_unstemmed	Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
title_sort	use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/775a7b8404e841fab4e5a57427c7b5a6
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Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study

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