Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study

Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Song Zhao, Jiamin Tang, Chen Chi, Yi Zhang, Yawei Xu Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Yi Zhang; Yawei XuDepartment...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maimaitiaili R, Teliewubai J, Zhao S, Tang J, Chi C, Zhang Y, Xu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	arteriosclerosis micro-albuminuria peripheral atherosclerosis community-dwelling elderly Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/775d47e15c1a4b26b0b129ea8b70837f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:775d47e15c1a4b26b0b129ea8b70837f
record_format	dspace
spelling	oai:doaj.org-article:775d47e15c1a4b26b0b129ea8b70837f2021-12-02T10:28:11ZRelationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study1178-1998https://doaj.org/article/775d47e15c1a4b26b0b129ea8b70837f2020-06-01T00:00:00Zhttps://www.dovepress.com/relationship-between-vascular-aging-and-left-ventricular-concentric-ge-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Song Zhao, Jiamin Tang, Chen Chi, Yi Zhang, Yawei Xu Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Yi Zhang; Yawei XuDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, People’s Republic of ChinaTel/ Fax +86 18917686332Email yizshcn@gmail.com; xuyawei@tongji.edu.cnPurpose: There have been few recent studies regarding vascular aging and its relationship with left ventricular (LV) geometry. Moreover, the association of abnormal LV geometry with various kinds of vascular aging has not yet been systematically analyzed. Thus, this study aimed to further elucidate this relationship.Materials and Methods: In this study, 3363 older participants (43.6% male, aged 71.1± 5.9 years; 56.4% female, aged 71.1± 6.1 years) derived from the Northern Shanghai Study were enrolled. Vascular aging criteria included arteriosclerosis, defined as carotid-femoral pulse wave velocity > 10 m/s or brachial–ankle pulse wave velocity > 1800 cm/s, and peripheral atherosclerosis, defined as ankle–brachial index < 0.9, carotid artery intima-media thickness (cIMT) greater than 0.9 mm, or carotid plaque indicating carotid artery abnormality. Micro-albuminuria was defined as urinary albumin-to-creatinine ratio > 30 mg/g. Decreased estimated glomerular filtration rate (eGFR) was defined as eGFR < 60 mL/min/1.73 m2.Results: When vascular aging parameters were respectively adjusted for age and sex, arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis were significantly associated with concentric remodeling, eccentric LV hypertrophy (LVH), and concentric LVH (P< 0.045) but not with decreased eGFR or abnormal cIMT and presence of plaque. Peripheral atherosclerosis was strongly associated with LV concentric geometry (LVCG) when considering other covariates (risk factors, diseases, and treatments) (P< 0.012).Conclusion: Vascular aging parameters such as arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis are significantly and independently associated with LVCG in community-dwelling older Chinese population, suggesting the importance of vascular aging during early clinical assessment of abnormal LV geometry change and serious cardiovascular events.Keywords: arteriosclerosis, micro-albuminuria, peripheral atherosclerosis, community-dwelling elderlyMaimaitiaili RTeliewubai JZhao STang JChi CZhang YXu YDove Medical Pressarticlearteriosclerosismicro-albuminuriaperipheral atherosclerosiscommunity-dwelling elderlyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 853-863 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	arteriosclerosis micro-albuminuria peripheral atherosclerosis community-dwelling elderly Geriatrics RC952-954.6
spellingShingle	arteriosclerosis micro-albuminuria peripheral atherosclerosis community-dwelling elderly Geriatrics RC952-954.6 Maimaitiaili R Teliewubai J Zhao S Tang J Chi C Zhang Y Xu Y Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study
description	Rusitanmujiang Maimaitiaili, Jiadela Teliewubai, Song Zhao, Jiamin Tang, Chen Chi, Yi Zhang, Yawei Xu Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Yi Zhang; Yawei XuDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, People’s Republic of ChinaTel/ Fax +86 18917686332Email yizshcn@gmail.com; xuyawei@tongji.edu.cnPurpose: There have been few recent studies regarding vascular aging and its relationship with left ventricular (LV) geometry. Moreover, the association of abnormal LV geometry with various kinds of vascular aging has not yet been systematically analyzed. Thus, this study aimed to further elucidate this relationship.Materials and Methods: In this study, 3363 older participants (43.6% male, aged 71.1± 5.9 years; 56.4% female, aged 71.1± 6.1 years) derived from the Northern Shanghai Study were enrolled. Vascular aging criteria included arteriosclerosis, defined as carotid-femoral pulse wave velocity > 10 m/s or brachial–ankle pulse wave velocity > 1800 cm/s, and peripheral atherosclerosis, defined as ankle–brachial index < 0.9, carotid artery intima-media thickness (cIMT) greater than 0.9 mm, or carotid plaque indicating carotid artery abnormality. Micro-albuminuria was defined as urinary albumin-to-creatinine ratio > 30 mg/g. Decreased estimated glomerular filtration rate (eGFR) was defined as eGFR < 60 mL/min/1.73 m2.Results: When vascular aging parameters were respectively adjusted for age and sex, arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis were significantly associated with concentric remodeling, eccentric LV hypertrophy (LVH), and concentric LVH (P< 0.045) but not with decreased eGFR or abnormal cIMT and presence of plaque. Peripheral atherosclerosis was strongly associated with LV concentric geometry (LVCG) when considering other covariates (risk factors, diseases, and treatments) (P< 0.012).Conclusion: Vascular aging parameters such as arteriosclerosis, micro-albuminuria, and peripheral atherosclerosis are significantly and independently associated with LVCG in community-dwelling older Chinese population, suggesting the importance of vascular aging during early clinical assessment of abnormal LV geometry change and serious cardiovascular events.Keywords: arteriosclerosis, micro-albuminuria, peripheral atherosclerosis, community-dwelling elderly
format	article
author	Maimaitiaili R Teliewubai J Zhao S Tang J Chi C Zhang Y Xu Y
author_facet	Maimaitiaili R Teliewubai J Zhao S Tang J Chi C Zhang Y Xu Y
author_sort	Maimaitiaili R
title	Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study
title_short	Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study
title_full	Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study
title_fullStr	Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study
title_full_unstemmed	Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study
title_sort	relationship between vascular aging and left ventricular concentric geometry in community-dwelling elderly: the northern shanghai study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/775d47e15c1a4b26b0b129ea8b70837f
work_keys_str_mv	AT maimaitiailir relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy AT teliewubaij relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy AT zhaos relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy AT tangj relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy AT chic relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy AT zhangy relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy AT xuy relationshipbetweenvascularagingandleftventricularconcentricgeometryincommunitydwellingelderlythenorthernshanghaistudy
_version_	1718397176238833664

Relationship Between Vascular Aging and Left Ventricular Concentric Geometry in Community-Dwelling Elderly: The Northern Shanghai Study

Ejemplares similares