Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis

High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and v...

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Autores principales:	Maria Siekkeri Vandikas, Kerstin Landin-Wilhelmsen, Sam Polesie, Martin Gillstedt, Amra Osmancevic
Formato:	article
Lenguaje:	EN
Publicado:	Society for Publication of Acta Dermato-Venereologica 2021
Materias:	psoriasis psoriatic arthritis tumour necrosis factor inhibitor vitamin D vitamin D-binding protein biomarker Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/775d710038504b648263405a25d2752b
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spelling	oai:doaj.org-article:775d710038504b648263405a25d2752b2021-11-24T13:54:08ZImpact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis10.2340/actadv.v101.3590001-55551651-2057https://doaj.org/article/775d710038504b648263405a25d2752b2021-11-01T00:00:00Zhttps://medicaljournalssweden.se/actadv/article/view/359https://doaj.org/toc/0001-5555https://doaj.org/toc/1651-2057High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and vitamin D-binding protein in patients with psoriasis. The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. A prospective observational study was performed, including 20 patients with psoriasis and 15 controls. Serum samples were analyzed for, among others, vitamin D metabolites, vitamin D-binding protein and highly sensitive C-reactive protein. Baseline levels of vitamin D-binding protein were higher in patients with self-reported arthropathy than in those without. After 24 weeks’ treatment, an improvement in psoriasis was noted, as was a decrease in highly sensitive C-reactive protein. Vitamin D-binding protein decreased in those with self-reported arthropathy. Higher baseline levels of vitamin D were associated with faster and greater improvement in psoriasis. Vitamin D-binding protein may have an inflammatory biomarker role. Maria Siekkeri VandikasKerstin Landin-WilhelmsenSam PolesieMartin GillstedtAmra OsmancevicSociety for Publication of Acta Dermato-Venereologicaarticlepsoriasispsoriatic arthritistumour necrosis factor inhibitorvitamin Dvitamin D-binding proteinbiomarkerDermatologyRL1-803ENActa Dermato-Venereologica, Vol 101, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis psoriatic arthritis tumour necrosis factor inhibitor vitamin D vitamin D-binding protein biomarker Dermatology RL1-803
spellingShingle	psoriasis psoriatic arthritis tumour necrosis factor inhibitor vitamin D vitamin D-binding protein biomarker Dermatology RL1-803 Maria Siekkeri Vandikas Kerstin Landin-Wilhelmsen Sam Polesie Martin Gillstedt Amra Osmancevic Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
description	High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and vitamin D-binding protein in patients with psoriasis. The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. A prospective observational study was performed, including 20 patients with psoriasis and 15 controls. Serum samples were analyzed for, among others, vitamin D metabolites, vitamin D-binding protein and highly sensitive C-reactive protein. Baseline levels of vitamin D-binding protein were higher in patients with self-reported arthropathy than in those without. After 24 weeks’ treatment, an improvement in psoriasis was noted, as was a decrease in highly sensitive C-reactive protein. Vitamin D-binding protein decreased in those with self-reported arthropathy. Higher baseline levels of vitamin D were associated with faster and greater improvement in psoriasis. Vitamin D-binding protein may have an inflammatory biomarker role.
format	article
author	Maria Siekkeri Vandikas Kerstin Landin-Wilhelmsen Sam Polesie Martin Gillstedt Amra Osmancevic
author_facet	Maria Siekkeri Vandikas Kerstin Landin-Wilhelmsen Sam Polesie Martin Gillstedt Amra Osmancevic
author_sort	Maria Siekkeri Vandikas
title	Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
title_short	Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
title_full	Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
title_fullStr	Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
title_full_unstemmed	Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis
title_sort	impact of etanercept on vitamin d status and vitamin d-binding protein in bio-naïve patients with psoriasis
publisher	Society for Publication of Acta Dermato-Venereologica
publishDate	2021
url	https://doaj.org/article/775d710038504b648263405a25d2752b
work_keys_str_mv	AT mariasiekkerivandikas impactofetanerceptonvitamindstatusandvitamindbindingproteininbionaivepatientswithpsoriasis AT kerstinlandinwilhelmsen impactofetanerceptonvitamindstatusandvitamindbindingproteininbionaivepatientswithpsoriasis AT sampolesie impactofetanerceptonvitamindstatusandvitamindbindingproteininbionaivepatientswithpsoriasis AT martingillstedt impactofetanerceptonvitamindstatusandvitamindbindingproteininbionaivepatientswithpsoriasis AT amraosmancevic impactofetanerceptonvitamindstatusandvitamindbindingproteininbionaivepatientswithpsoriasis
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Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis

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