Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with the kinase TAK1.

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Autores principales:	Pi-Xiao Wang, Xiao-Jing Zhang, Pengcheng Luo, Xi Jiang, Peng Zhang, Junhong Guo, Guang-Nian Zhao, Xueyong Zhu, Yan Zhang, Sijun Yang, Hongliang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77626b712e6848859314d54a4402770d
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spelling	oai:doaj.org-article:77626b712e6848859314d54a4402770d2021-12-02T16:58:11ZHepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling10.1038/ncomms105922041-1723https://doaj.org/article/77626b712e6848859314d54a4402770d2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10592https://doaj.org/toc/2041-1723TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with the kinase TAK1.Pi-Xiao WangXiao-Jing ZhangPengcheng LuoXi JiangPeng ZhangJunhong GuoGuang-Nian ZhaoXueyong ZhuYan ZhangSijun YangHongliang LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-22 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pi-Xiao Wang Xiao-Jing Zhang Pengcheng Luo Xi Jiang Peng Zhang Junhong Guo Guang-Nian Zhao Xueyong Zhu Yan Zhang Sijun Yang Hongliang Li Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
description	TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with the kinase TAK1.
format	article
author	Pi-Xiao Wang Xiao-Jing Zhang Pengcheng Luo Xi Jiang Peng Zhang Junhong Guo Guang-Nian Zhao Xueyong Zhu Yan Zhang Sijun Yang Hongliang Li
author_facet	Pi-Xiao Wang Xiao-Jing Zhang Pengcheng Luo Xi Jiang Peng Zhang Junhong Guo Guang-Nian Zhao Xueyong Zhu Yan Zhang Sijun Yang Hongliang Li
author_sort	Pi-Xiao Wang
title	Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
title_short	Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
title_full	Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
title_fullStr	Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
title_full_unstemmed	Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
title_sort	hepatocyte traf3 promotes liver steatosis and systemic insulin resistance through targeting tak1-dependent signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/77626b712e6848859314d54a4402770d
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Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

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