An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

In breast cancer, the immune infiltration of the tumour associates with clinical outcome. Here, the authors infer immune context based on gene expression data and identify a new independent subtype linked to pro-tumorigenic immune infiltration.

Guardado en:
Detalles Bibliográficos
Autores principales: Xavier Tekpli, Tonje Lien, Andreas Hagen Røssevold, Daniel Nebdal, Elin Borgen, Hege Oma Ohnstad, Jon Amund Kyte, Johan Vallon-Christersson, Marie Fongaard, Eldri Undlien Due, Lisa Gregusson Svartdal, My Anh Tu Sveli, Øystein Garred, OSBREAC, Arnoldo Frigessi, Kristine Kleivi Sahlberg, Therese Sørlie, Hege G. Russnes, Bjørn Naume, Vessela N. Kristensen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/77641556908e44e9aa2cd197f5b2e87b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:77641556908e44e9aa2cd197f5b2e87b
record_format dspace
spelling oai:doaj.org-article:77641556908e44e9aa2cd197f5b2e87b2021-12-02T15:36:01ZAn independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment10.1038/s41467-019-13329-52041-1723https://doaj.org/article/77641556908e44e9aa2cd197f5b2e87b2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13329-5https://doaj.org/toc/2041-1723In breast cancer, the immune infiltration of the tumour associates with clinical outcome. Here, the authors infer immune context based on gene expression data and identify a new independent subtype linked to pro-tumorigenic immune infiltration.Xavier TekpliTonje LienAndreas Hagen RøssevoldDaniel NebdalElin BorgenHege Oma OhnstadJon Amund KyteJohan Vallon-ChristerssonMarie FongaardEldri Undlien DueLisa Gregusson SvartdalMy Anh Tu SveliØystein GarredOSBREACArnoldo FrigessiKristine Kleivi SahlbergTherese SørlieHege G. RussnesBjørn NaumeVessela N. KristensenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xavier Tekpli
Tonje Lien
Andreas Hagen Røssevold
Daniel Nebdal
Elin Borgen
Hege Oma Ohnstad
Jon Amund Kyte
Johan Vallon-Christersson
Marie Fongaard
Eldri Undlien Due
Lisa Gregusson Svartdal
My Anh Tu Sveli
Øystein Garred
OSBREAC
Arnoldo Frigessi
Kristine Kleivi Sahlberg
Therese Sørlie
Hege G. Russnes
Bjørn Naume
Vessela N. Kristensen
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
description In breast cancer, the immune infiltration of the tumour associates with clinical outcome. Here, the authors infer immune context based on gene expression data and identify a new independent subtype linked to pro-tumorigenic immune infiltration.
format article
author Xavier Tekpli
Tonje Lien
Andreas Hagen Røssevold
Daniel Nebdal
Elin Borgen
Hege Oma Ohnstad
Jon Amund Kyte
Johan Vallon-Christersson
Marie Fongaard
Eldri Undlien Due
Lisa Gregusson Svartdal
My Anh Tu Sveli
Øystein Garred
OSBREAC
Arnoldo Frigessi
Kristine Kleivi Sahlberg
Therese Sørlie
Hege G. Russnes
Bjørn Naume
Vessela N. Kristensen
author_facet Xavier Tekpli
Tonje Lien
Andreas Hagen Røssevold
Daniel Nebdal
Elin Borgen
Hege Oma Ohnstad
Jon Amund Kyte
Johan Vallon-Christersson
Marie Fongaard
Eldri Undlien Due
Lisa Gregusson Svartdal
My Anh Tu Sveli
Øystein Garred
OSBREAC
Arnoldo Frigessi
Kristine Kleivi Sahlberg
Therese Sørlie
Hege G. Russnes
Bjørn Naume
Vessela N. Kristensen
author_sort Xavier Tekpli
title An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
title_short An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
title_full An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
title_fullStr An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
title_full_unstemmed An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
title_sort independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/77641556908e44e9aa2cd197f5b2e87b
work_keys_str_mv AT xaviertekpli anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT tonjelien anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT andreashagenrøssevold anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT danielnebdal anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT elinborgen anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT hegeomaohnstad anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT jonamundkyte anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT johanvallonchristersson anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT mariefongaard anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT eldriundliendue anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT lisagregussonsvartdal anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT myanhtusveli anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT øysteingarred anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT osbreac anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT arnoldofrigessi anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT kristinekleivisahlberg anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT theresesørlie anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT hegegrussnes anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT bjørnnaume anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT vesselankristensen anindependentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT xaviertekpli independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT tonjelien independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT andreashagenrøssevold independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT danielnebdal independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT elinborgen independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT hegeomaohnstad independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT jonamundkyte independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT johanvallonchristersson independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT mariefongaard independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT eldriundliendue independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT lisagregussonsvartdal independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT myanhtusveli independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT øysteingarred independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT osbreac independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT arnoldofrigessi independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT kristinekleivisahlberg independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT theresesørlie independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT hegegrussnes independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT bjørnnaume independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
AT vesselankristensen independentpoorprognosissubtypeofbreastcancerdefinedbyadistincttumorimmunemicroenvironment
_version_ 1718386360768790528

Ejemplares similares