The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress

The bacterial pathogen Helicobacter pylori is known for its ability to induce DNA double-strand breaks in the genome of its target cells. Here, we show that H. pylori-induced DNA damage and replication stress occurs in S-phase cells as a result of R-loop-mediated transcription/replication conflicts...

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Autores principales:	Michael Bauer, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Töpfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Anne Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/776595ded02849959ccfec289f6e8902
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spelling	oai:doaj.org-article:776595ded02849959ccfec289f6e89022021-12-02T16:56:44ZThe ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress10.1038/s41467-020-18857-z2041-1723https://doaj.org/article/776595ded02849959ccfec289f6e89022020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18857-zhttps://doaj.org/toc/2041-1723The bacterial pathogen Helicobacter pylori is known for its ability to induce DNA double-strand breaks in the genome of its target cells. Here, we show that H. pylori-induced DNA damage and replication stress occurs in S-phase cells as a result of R-loop-mediated transcription/replication conflicts that are triggered by activation of the ALPK1/TIFA/NF-κB signaling axis.Michael BauerZuzana NascakovaAnca-Irina MihaiPhil F. ChengMitchell P. LevesqueSimon LampartRobert HurwitzLennart PfannkuchJana DobrovolnaMelanie JacobsSina BartfeldAnders DohlmanXiling ShenAlevtina A. GallNina R. SalamaAntonia TöpferAchim WeberThomas F. MeyerPavel JanscakAnne MüllerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Bauer Zuzana Nascakova Anca-Irina Mihai Phil F. Cheng Mitchell P. Levesque Simon Lampart Robert Hurwitz Lennart Pfannkuch Jana Dobrovolna Melanie Jacobs Sina Bartfeld Anders Dohlman Xiling Shen Alevtina A. Gall Nina R. Salama Antonia Töpfer Achim Weber Thomas F. Meyer Pavel Janscak Anne Müller The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
description	The bacterial pathogen Helicobacter pylori is known for its ability to induce DNA double-strand breaks in the genome of its target cells. Here, we show that H. pylori-induced DNA damage and replication stress occurs in S-phase cells as a result of R-loop-mediated transcription/replication conflicts that are triggered by activation of the ALPK1/TIFA/NF-κB signaling axis.
format	article
author	Michael Bauer Zuzana Nascakova Anca-Irina Mihai Phil F. Cheng Mitchell P. Levesque Simon Lampart Robert Hurwitz Lennart Pfannkuch Jana Dobrovolna Melanie Jacobs Sina Bartfeld Anders Dohlman Xiling Shen Alevtina A. Gall Nina R. Salama Antonia Töpfer Achim Weber Thomas F. Meyer Pavel Janscak Anne Müller
author_facet	Michael Bauer Zuzana Nascakova Anca-Irina Mihai Phil F. Cheng Mitchell P. Levesque Simon Lampart Robert Hurwitz Lennart Pfannkuch Jana Dobrovolna Melanie Jacobs Sina Bartfeld Anders Dohlman Xiling Shen Alevtina A. Gall Nina R. Salama Antonia Töpfer Achim Weber Thomas F. Meyer Pavel Janscak Anne Müller
author_sort	Michael Bauer
title	The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
title_short	The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
title_full	The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
title_fullStr	The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
title_full_unstemmed	The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
title_sort	alpk1/tifa/nf-κb axis links a bacterial carcinogen to r-loop-induced replication stress
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/776595ded02849959ccfec289f6e8902
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The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress

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