The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
The bacterial pathogen Helicobacter pylori is known for its ability to induce DNA double-strand breaks in the genome of its target cells. Here, we show that H. pylori-induced DNA damage and replication stress occurs in S-phase cells as a result of R-loop-mediated transcription/replication conflicts...
Guardado en:
Autores principales: | Michael Bauer, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Töpfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Anne Müller |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/776595ded02849959ccfec289f6e8902 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
TIFA Signaling in Gastric Epithelial Cells Initiates the <italic toggle="yes">cag</italic> Type 4 Secretion System-Dependent Innate Immune Response to <italic toggle="yes">Helicobacter pylori</italic> Infection
por: Alevtina Gall, et al.
Publicado: (2017) -
TIFA protein expression is associated with pulmonary arterial hypertension
por: Hao-Chih Chang, et al.
Publicado: (2021) -
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
por: Mamunur Rashid, et al.
Publicado: (2019) -
The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells.
por: Jiannan Cui, et al.
Publicado: (2021) -
Thirdhand smoke: Genotoxicity and carcinogenic potential
por: Bo Hang, et al.
Publicado: (2020)