Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy

<h4>Objectives</h4> We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT. <h4>Methods</h4> This secondary analysis of patients with major depression (N = 136; 63% female; age...

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Autores principales:	Caoimhe Fenton, Declan M. McLoughlin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7766f801f43a44d49b48e2e2c947ee20
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spelling	oai:doaj.org-article:7766f801f43a44d49b48e2e2c947ee202021-11-18T06:34:42ZUsefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy1932-6203https://doaj.org/article/7766f801f43a44d49b48e2e2c947ee202021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577745/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4> We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT. <h4>Methods</h4> This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three ‘full’ versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items. <h4>Results</h4> The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission. <h4>Conclusions</h4> Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.Caoimhe FentonDeclan M. McLoughlinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caoimhe Fenton Declan M. McLoughlin Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
description	<h4>Objectives</h4> We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT. <h4>Methods</h4> This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three ‘full’ versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items. <h4>Results</h4> The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission. <h4>Conclusions</h4> Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.
format	article
author	Caoimhe Fenton Declan M. McLoughlin
author_facet	Caoimhe Fenton Declan M. McLoughlin
author_sort	Caoimhe Fenton
title	Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
title_short	Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
title_full	Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
title_fullStr	Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
title_full_unstemmed	Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
title_sort	usefulness of hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7766f801f43a44d49b48e2e2c947ee20
work_keys_str_mv	AT caoimhefenton usefulnessofhamiltonratingscalefordepressionsubsetscalesandfullversionsforelectroconvulsivetherapy AT declanmmcloughlin usefulnessofhamiltonratingscalefordepressionsubsetscalesandfullversionsforelectroconvulsivetherapy
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Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy

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