γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES

Abstract. γδТ lymphocytes represent a poorly investigated heterogeneous population of T cells that are found, predominantly, in mucosal structures, and express common characteristics of innate and acquired immunity. Lack of both antigen processing and MHC-restriction determines an ability of γδТ cel...

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Autores principales:	D. B. Nizhegorodova, M. M. Zafranskaya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	γδт-lymphocytes phosphoantigens cytotoxicity immuneregulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/776aa16e703a441fa4da32342fcdd211
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spelling	oai:doaj.org-article:776aa16e703a441fa4da32342fcdd2112021-11-18T08:03:39ZγδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES1563-06252313-741X10.15789/1563-0625-2009-2-3-115-130https://doaj.org/article/776aa16e703a441fa4da32342fcdd2112014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/267https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. γδТ lymphocytes represent a poorly investigated heterogeneous population of T cells that are found, predominantly, in mucosal structures, and express common characteristics of innate and acquired immunity. Lack of both antigen processing and MHC-restriction determines an ability of γδТ cells to identify broad spectrum of antigens, the origin of which is yet unknown, and the recognition mechanism have been not established yet. A variety of biological functions, first of all, cytolysis, immune regulation, antigen presentation and repair of tissue damage, define a unique role of this population in infectious diseases, tumors, and autoimmune disorders. Nowadays, principal efforts of scientists are directed to investigation of γδТ cell therapeutic potential, search and production of γδТ cell agonists, as well as design and optimization of herapeutic protocols that may be targeted to γδТ lymphocytes.D. B. NizhegorodovaM. M. ZafranskayaSPb RAACIarticleγδт-lymphocytesphosphoantigenscytotoxicityimmuneregulationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 115-130 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	γδт-lymphocytes phosphoantigens cytotoxicity immuneregulation Immunologic diseases. Allergy RC581-607
spellingShingle	γδт-lymphocytes phosphoantigens cytotoxicity immuneregulation Immunologic diseases. Allergy RC581-607 D. B. Nizhegorodova M. M. Zafranskaya γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
description	Abstract. γδТ lymphocytes represent a poorly investigated heterogeneous population of T cells that are found, predominantly, in mucosal structures, and express common characteristics of innate and acquired immunity. Lack of both antigen processing and MHC-restriction determines an ability of γδТ cells to identify broad spectrum of antigens, the origin of which is yet unknown, and the recognition mechanism have been not established yet. A variety of biological functions, first of all, cytolysis, immune regulation, antigen presentation and repair of tissue damage, define a unique role of this population in infectious diseases, tumors, and autoimmune disorders. Nowadays, principal efforts of scientists are directed to investigation of γδТ cell therapeutic potential, search and production of γδТ cell agonists, as well as design and optimization of herapeutic protocols that may be targeted to γδТ lymphocytes.
format	article
author	D. B. Nizhegorodova M. M. Zafranskaya
author_facet	D. B. Nizhegorodova M. M. Zafranskaya
author_sort	D. B. Nizhegorodova
title	γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
title_short	γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
title_full	γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
title_fullStr	γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
title_full_unstemmed	γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
title_sort	γδт-lymphocytes: general characteristics, subpopulation profile, biological role, and functional features
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/776aa16e703a441fa4da32342fcdd211
work_keys_str_mv	AT dbnizhegorodova gdtlymphocytesgeneralcharacteristicssubpopulationprofilebiologicalroleandfunctionalfeatures AT mmzafranskaya gdtlymphocytesgeneralcharacteristicssubpopulationprofilebiologicalroleandfunctionalfeatures
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γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES

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