Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy

Daniel Ben Ner,1,2 Ifat Sher,1 Amit Hamburg,1,2 Mohamad O Mhajna,1,2 Ron Chibel,1,2 Estela Derazne,2 Inbal Sharvit-Ginon,3,4 Eran Pras,2,5 Hadas Newman,2,6 Jaime Levy,7 Samer Khateb,7 Dror Sharon,7 Ygal Rotenstreich1,2 1Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel; 2Sackle...

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Autores principales:	Ben Ner D, Sher I, Hamburg A, Mhajna MO, Chibel R, Derazne E, Sharvit-Ginon I, Pras E, Newman H, Levy J, Khateb S, Sharon D, Rotenstreich Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Best Vitelliform Macular Dystrophy BVMD Pupillary Light Reflex Perimetry Pupilloperimetry Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/77724cf513164e5298e007a552442fda
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spelling	oai:doaj.org-article:77724cf513164e5298e007a552442fda2021-12-02T03:12:22ZChromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy1177-5483https://doaj.org/article/77724cf513164e5298e007a552442fda2019-03-01T00:00:00Zhttps://www.dovepress.com/chromatic-pupilloperimetry-for-objective-diagnosis-of-best-vitelliform-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Daniel Ben Ner,1,2 Ifat Sher,1 Amit Hamburg,1,2 Mohamad O Mhajna,1,2 Ron Chibel,1,2 Estela Derazne,2 Inbal Sharvit-Ginon,3,4 Eran Pras,2,5 Hadas Newman,2,6 Jaime Levy,7 Samer Khateb,7 Dror Sharon,7 Ygal Rotenstreich1,2 1Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Psychology, Bar Ilan University, Ramat Gan, Israel; 4The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel; 5The Matlow’s Ophthalmo-Genetics Laboratory, Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel; 6Ophthalmology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 7Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel Purpose: To determine the pupil response of Best vitelliform macular dystrophy (BVMD) patients for focal blue and red light stimuli presented at 76 test points in a 16.2° visual field (VF) using a chromatic pupilloperimeter.Methods: An observational study was conducted in 16 participants: 7 BVMD patients with a heterozygous BEST1 mutation and 9 similar-aged controls. All participants were tested for best-corrected visual acuity, chromatic pupilloperimetry and Humphrey perimetry. Percentage of pupil contraction (PPC), maximal pupil contraction velocity (MCV) and latency of MCV (LMCV) were determined.Results: The mean PPC and MCV recorded in BVMD patients in response to red stimuli were lower by >2 standard errors (SEs) from the mean of controls in 47% and 43% of VF test points, respectively. The mean PPC and MCV recorded in the patients in response to blue stimuli were lower by >2 SEs from the mean of controls in 36% and 24% of VF test points, respectively. The patients’ mean and median MCV recorded in response to red light correlated with their Humphrey mean deviation score (r=−0.714, P=0.071 and r=−0.821, P=0.023, respectively) and visual acuity (r=0.709, P=0.074 and r=0.655, P=0.111, respectively). A substantially shorter mean LMCV was recorded in BVMD patients compared to controls in 54% and 93% of VF test points in response to red and blue light, respectively. Receiver operating characteristic analysis for LMCV in response to red light identified a test point at the center of the VF with high diagnostic accuracy (area under the curve of 0.94).Conclusion: Chromatic pupilloperimetry may potentially be used for objective noninvasive assessment of rod and cone cell function in different locations of the retina in BVMD patients. Keywords: Best vitelliform macular dystrophy, pupillary light reflex, perimetry, pupilloperimetry, visual fieldBen Ner DSher IHamburg AMhajna MOChibel RDerazne ESharvit-Ginon IPras ENewman HLevy JKhateb SSharon DRotenstreich YDove Medical PressarticleBest Vitelliform Macular DystrophyBVMDPupillary Light ReflexPerimetryPupilloperimetryOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 465-475 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Best Vitelliform Macular Dystrophy BVMD Pupillary Light Reflex Perimetry Pupilloperimetry Ophthalmology RE1-994
spellingShingle	Best Vitelliform Macular Dystrophy BVMD Pupillary Light Reflex Perimetry Pupilloperimetry Ophthalmology RE1-994 Ben Ner D Sher I Hamburg A Mhajna MO Chibel R Derazne E Sharvit-Ginon I Pras E Newman H Levy J Khateb S Sharon D Rotenstreich Y Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy
description	Daniel Ben Ner,1,2 Ifat Sher,1 Amit Hamburg,1,2 Mohamad O Mhajna,1,2 Ron Chibel,1,2 Estela Derazne,2 Inbal Sharvit-Ginon,3,4 Eran Pras,2,5 Hadas Newman,2,6 Jaime Levy,7 Samer Khateb,7 Dror Sharon,7 Ygal Rotenstreich1,2 1Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Psychology, Bar Ilan University, Ramat Gan, Israel; 4The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel; 5The Matlow’s Ophthalmo-Genetics Laboratory, Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel; 6Ophthalmology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 7Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel Purpose: To determine the pupil response of Best vitelliform macular dystrophy (BVMD) patients for focal blue and red light stimuli presented at 76 test points in a 16.2° visual field (VF) using a chromatic pupilloperimeter.Methods: An observational study was conducted in 16 participants: 7 BVMD patients with a heterozygous BEST1 mutation and 9 similar-aged controls. All participants were tested for best-corrected visual acuity, chromatic pupilloperimetry and Humphrey perimetry. Percentage of pupil contraction (PPC), maximal pupil contraction velocity (MCV) and latency of MCV (LMCV) were determined.Results: The mean PPC and MCV recorded in BVMD patients in response to red stimuli were lower by >2 standard errors (SEs) from the mean of controls in 47% and 43% of VF test points, respectively. The mean PPC and MCV recorded in the patients in response to blue stimuli were lower by >2 SEs from the mean of controls in 36% and 24% of VF test points, respectively. The patients’ mean and median MCV recorded in response to red light correlated with their Humphrey mean deviation score (r=−0.714, P=0.071 and r=−0.821, P=0.023, respectively) and visual acuity (r=0.709, P=0.074 and r=0.655, P=0.111, respectively). A substantially shorter mean LMCV was recorded in BVMD patients compared to controls in 54% and 93% of VF test points in response to red and blue light, respectively. Receiver operating characteristic analysis for LMCV in response to red light identified a test point at the center of the VF with high diagnostic accuracy (area under the curve of 0.94).Conclusion: Chromatic pupilloperimetry may potentially be used for objective noninvasive assessment of rod and cone cell function in different locations of the retina in BVMD patients. Keywords: Best vitelliform macular dystrophy, pupillary light reflex, perimetry, pupilloperimetry, visual field
format	article
author	Ben Ner D Sher I Hamburg A Mhajna MO Chibel R Derazne E Sharvit-Ginon I Pras E Newman H Levy J Khateb S Sharon D Rotenstreich Y
author_facet	Ben Ner D Sher I Hamburg A Mhajna MO Chibel R Derazne E Sharvit-Ginon I Pras E Newman H Levy J Khateb S Sharon D Rotenstreich Y
author_sort	Ben Ner D
title	Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy
title_short	Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy
title_full	Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy
title_fullStr	Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy
title_full_unstemmed	Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy
title_sort	chromatic pupilloperimetry for objective diagnosis of best vitelliform macular dystrophy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/77724cf513164e5298e007a552442fda
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Chromatic pupilloperimetry for objective diagnosis of Best vitelliform macular dystrophy

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