Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples

In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in total human plasma.

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Autores principales:	Guinevere S. M. Lageveen-Kammeijer, Noortje de Haan, Pablo Mohaupt, Sander Wagt, Mike Filius, Jan Nouta, David Falck, Manfred Wuhrer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77741c56da574b2796a64fd252a00dda
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spelling	oai:doaj.org-article:77741c56da574b2796a64fd252a00dda2021-12-02T16:57:21ZHighly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples10.1038/s41467-019-09910-72041-1723https://doaj.org/article/77741c56da574b2796a64fd252a00dda2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09910-7https://doaj.org/toc/2041-1723In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in total human plasma.Guinevere S. M. Lageveen-KammeijerNoortje de HaanPablo MohauptSander WagtMike FiliusJan NoutaDavid FalckManfred WuhrerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guinevere S. M. Lageveen-Kammeijer Noortje de Haan Pablo Mohaupt Sander Wagt Mike Filius Jan Nouta David Falck Manfred Wuhrer Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
description	In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in total human plasma.
format	article
author	Guinevere S. M. Lageveen-Kammeijer Noortje de Haan Pablo Mohaupt Sander Wagt Mike Filius Jan Nouta David Falck Manfred Wuhrer
author_facet	Guinevere S. M. Lageveen-Kammeijer Noortje de Haan Pablo Mohaupt Sander Wagt Mike Filius Jan Nouta David Falck Manfred Wuhrer
author_sort	Guinevere S. M. Lageveen-Kammeijer
title	Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
title_short	Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
title_full	Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
title_fullStr	Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
title_full_unstemmed	Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
title_sort	highly sensitive ce-esi-ms analysis of n-glycans from complex biological samples
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/77741c56da574b2796a64fd252a00dda
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Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples

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