Chest Radiographs and CT Findings during Healthcare Workers’ Tuberculosis Screening Using Interferon- Gamma Release Assay: Retrospective Observational Study
Purpose To investigate the incidence of tuberculosis (TB) in healthcare workers (HCWs) with positive interferon-gamma release assay (IGRA) results based on chest X-ray (CXR) and CT findings and determine the role of imaging in the diagnosis of TB. Materials and Methods Among 1976 hospital personn...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN KO |
| Publicado: |
The Korean Society of Radiology
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/777e1f8c902e43549f6217d775d731cc |
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| Sumario: | Purpose To investigate the incidence of tuberculosis (TB) in healthcare workers (HCWs) with
positive interferon-gamma release assay (IGRA) results based on chest X-ray (CXR) and CT findings
and determine the role of imaging in the diagnosis of TB.
Materials and Methods Among 1976 hospital personnel screened for TB using IGRA, IGRApositive
subjects were retrospectively investigated. Clustered nodular and/or linear streaky
opacities in the upper lung zone were considered positive on CXR. The CT findings were classified
as active, indeterminate, inactive, or normal. The active or indeterminate class was considered
CT-positive.
Results IGRA was positive in 255 subjects (12.9%). CXR and CT were performed in 249 (99.2%)
and 113 subjects (45.0%), respectively. CXR- and CT-positive findings were found in 7 of 249
(2.8%) and 9 of 113 (8.0%) patients, respectively. Among the nine CT-positive subjects, active
and indeterminate TB findings were found in 6 (5.3%) and 3 (2.7%) patients, respectively.
Microbiological tests, including acid-fast bacilli staining, culture, and polymerase chain action for TB, were negative in all nine CT-positive subjects. Empirical anti-TB medications were
administered to 9 CT-positive subjects, and 3 of these nine subjects were CXR-negative for pulmonary TB.
Conclusion CT helped diagnose asymptomatic TB in IGRA-positive HCWs. |
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