Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells

Abstract Tobacco smoking is the leading preventable cause of cancer. Moreover, continued smoking during cancer therapy reduces overall survival. Aware of the negative consequences of tobacco smoking and the challenges of smoking cessation, cancer patients are inquiring whether they should switch to...

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Autores principales:	Jimmy Manyanga, Vengatesh Ganapathy, Célia Bouharati, Toral Mehta, Balaji Sadhasivam, Pawan Acharya, Daniel Zhao, Lurdes Queimado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/777e74d2b872400796474d49449f5c9c
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spelling	oai:doaj.org-article:777e74d2b872400796474d49449f5c9c2021-12-02T15:23:28ZElectronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells10.1038/s41598-021-81148-02045-2322https://doaj.org/article/777e74d2b872400796474d49449f5c9c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81148-0https://doaj.org/toc/2045-2322Abstract Tobacco smoking is the leading preventable cause of cancer. Moreover, continued smoking during cancer therapy reduces overall survival. Aware of the negative consequences of tobacco smoking and the challenges of smoking cessation, cancer patients are inquiring whether they should switch to electronic cigarettes (e-cigarettes). To obtain evidence-based data to inform this decision, we examined the effects of e-cigarette aerosol exposure on cisplatin resistance in head and neck cancer cells. Our results show that cancer cells exposed to e-cigarette aerosol extracts and treated with cisplatin have a significant decrease in cell death, increase in viability, and increase in clonogenic survival when compared to non-exposed cells. Moreover, exposure to e-cigarette aerosol extracts increased the concentration of cisplatin needed to induce a 50% reduction in cell growth (IC50) in a nicotine-independent manner. Tobacco smoke extracts induced similar increases in cisplatin resistance. Changes in the expression of drug influx and efflux transporters, rather than activation of cell growth-promoting pathways or DNA damage repair, contribute to e-cigarette induced cisplatin resistance. These results suggest that like combustible tobacco, e-cigarette use might increase chemotherapy resistance, and emphasize the urgent need for rigorous evaluation of e-cigarettes health effects to ensure evidence-based public health policies.Jimmy ManyangaVengatesh GanapathyCélia BouharatiToral MehtaBalaji SadhasivamPawan AcharyaDaniel ZhaoLurdes QueimadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jimmy Manyanga Vengatesh Ganapathy Célia Bouharati Toral Mehta Balaji Sadhasivam Pawan Acharya Daniel Zhao Lurdes Queimado Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
description	Abstract Tobacco smoking is the leading preventable cause of cancer. Moreover, continued smoking during cancer therapy reduces overall survival. Aware of the negative consequences of tobacco smoking and the challenges of smoking cessation, cancer patients are inquiring whether they should switch to electronic cigarettes (e-cigarettes). To obtain evidence-based data to inform this decision, we examined the effects of e-cigarette aerosol exposure on cisplatin resistance in head and neck cancer cells. Our results show that cancer cells exposed to e-cigarette aerosol extracts and treated with cisplatin have a significant decrease in cell death, increase in viability, and increase in clonogenic survival when compared to non-exposed cells. Moreover, exposure to e-cigarette aerosol extracts increased the concentration of cisplatin needed to induce a 50% reduction in cell growth (IC50) in a nicotine-independent manner. Tobacco smoke extracts induced similar increases in cisplatin resistance. Changes in the expression of drug influx and efflux transporters, rather than activation of cell growth-promoting pathways or DNA damage repair, contribute to e-cigarette induced cisplatin resistance. These results suggest that like combustible tobacco, e-cigarette use might increase chemotherapy resistance, and emphasize the urgent need for rigorous evaluation of e-cigarettes health effects to ensure evidence-based public health policies.
format	article
author	Jimmy Manyanga Vengatesh Ganapathy Célia Bouharati Toral Mehta Balaji Sadhasivam Pawan Acharya Daniel Zhao Lurdes Queimado
author_facet	Jimmy Manyanga Vengatesh Ganapathy Célia Bouharati Toral Mehta Balaji Sadhasivam Pawan Acharya Daniel Zhao Lurdes Queimado
author_sort	Jimmy Manyanga
title	Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
title_short	Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
title_full	Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
title_fullStr	Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
title_full_unstemmed	Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
title_sort	electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/777e74d2b872400796474d49449f5c9c
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Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells

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