THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY

The problem of studying cardiovascular diseases (CVD) for a long time remains extremely important, and, therefore, there are many works that offer new ways to diagnose and treat this group of diseases. Great opportunities are provided by the study of molecular interactions for a more accurate unders...

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Autores principales:	O. A. Ponasenko, L. V. Gankovskaya, O. A. Svitich
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	heat shock protein cardiovascular diseases arterial hypertension inflammation atherosclerosis immune mechanisms Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/77815d11da104f57afcf87618f49599f
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spelling	oai:doaj.org-article:77815d11da104f57afcf87618f49599f2021-11-18T08:03:48ZTHE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY1563-06252313-741X10.15789/1563-0625-2019-2-201-208https://doaj.org/article/77815d11da104f57afcf87618f49599f2019-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1520https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe problem of studying cardiovascular diseases (CVD) for a long time remains extremely important, and, therefore, there are many works that offer new ways to diagnose and treat this group of diseases. Great opportunities are provided by the study of molecular interactions for a more accurate understanding of the pathogenesis of cardiovascular pathology. Many studies have recently been devoted to finding potential markers of CVD risk with the aim of more accurate and early diagnosis. In this review we analyze the latest literature data dedicated to the role of heat shock protein 70 (HSP70) in cardiovascular pathology. HSP70 take part in such processes as arterial hypertension, coronary heart disease, and atherosclerosis. In atherogenesis, serum heat shock proteins 70 play a major role. It has been proven that in patients with a high concentration of heat shock protein molecules circulating in the blood, increased values of the carotid intima-media complex were observed. The important role of antibodies to circulating HSP70 is noted. Found an association of high levels of these antibodies with atherosclerosis in patients with arterial hypertension in history, with myocardial infarction. Low levels of anti-HSP70 antibodies are observed in patients with acute coronary syndrome. This proves the complexity of the mechanism and the dual role of antibodies against serum heat shock proteins 70. Thus, antibodies against heat shock proteins 70 can be assessed as a protective marker, and as a predictor, which requires further study, and the HSP70 molecules themselves can somehow to participate in the development of cardiovascular pathologies. Much attention is paid to the role of the inflammatory process and the mechanisms of innate immunity in CVD. As it is currently believed that Danger-associated molecular patterns (DAMPs) are involved in the pathogenesis of these pathologies in the context of a “hazard/damage” model. According to this model, the triggering factor is stress, leading to the release of DAMPs and their binding to innate immunity receptors - Toll-like receptors (TLRs). Activation of TLRs triggers the signaling cascade in the cell leading to the synthesis of pro-inflammatory cytokines. This contributes to the development of inflammation, which can provoke the emergence of new pathological processes in the body and worsen the course of existing diseases. The identification of new potential markers and knowledge of the molecular mechanisms of the pathogenesis of CVD can play an important role in the development of a new individual approach to the prevention of cardiovascular diseases.O. A. PonasenkoL. V. GankovskayaO. A. SvitichSPb RAACIarticleheat shock proteincardiovascular diseasesarterial hypertensioninflammationatherosclerosisimmune mechanismsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 2, Pp 201-208 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	heat shock protein cardiovascular diseases arterial hypertension inflammation atherosclerosis immune mechanisms Immunologic diseases. Allergy RC581-607
spellingShingle	heat shock protein cardiovascular diseases arterial hypertension inflammation atherosclerosis immune mechanisms Immunologic diseases. Allergy RC581-607 O. A. Ponasenko L. V. Gankovskaya O. A. Svitich THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY
description	The problem of studying cardiovascular diseases (CVD) for a long time remains extremely important, and, therefore, there are many works that offer new ways to diagnose and treat this group of diseases. Great opportunities are provided by the study of molecular interactions for a more accurate understanding of the pathogenesis of cardiovascular pathology. Many studies have recently been devoted to finding potential markers of CVD risk with the aim of more accurate and early diagnosis. In this review we analyze the latest literature data dedicated to the role of heat shock protein 70 (HSP70) in cardiovascular pathology. HSP70 take part in such processes as arterial hypertension, coronary heart disease, and atherosclerosis. In atherogenesis, serum heat shock proteins 70 play a major role. It has been proven that in patients with a high concentration of heat shock protein molecules circulating in the blood, increased values of the carotid intima-media complex were observed. The important role of antibodies to circulating HSP70 is noted. Found an association of high levels of these antibodies with atherosclerosis in patients with arterial hypertension in history, with myocardial infarction. Low levels of anti-HSP70 antibodies are observed in patients with acute coronary syndrome. This proves the complexity of the mechanism and the dual role of antibodies against serum heat shock proteins 70. Thus, antibodies against heat shock proteins 70 can be assessed as a protective marker, and as a predictor, which requires further study, and the HSP70 molecules themselves can somehow to participate in the development of cardiovascular pathologies. Much attention is paid to the role of the inflammatory process and the mechanisms of innate immunity in CVD. As it is currently believed that Danger-associated molecular patterns (DAMPs) are involved in the pathogenesis of these pathologies in the context of a “hazard/damage” model. According to this model, the triggering factor is stress, leading to the release of DAMPs and their binding to innate immunity receptors - Toll-like receptors (TLRs). Activation of TLRs triggers the signaling cascade in the cell leading to the synthesis of pro-inflammatory cytokines. This contributes to the development of inflammation, which can provoke the emergence of new pathological processes in the body and worsen the course of existing diseases. The identification of new potential markers and knowledge of the molecular mechanisms of the pathogenesis of CVD can play an important role in the development of a new individual approach to the prevention of cardiovascular diseases.
format	article
author	O. A. Ponasenko L. V. Gankovskaya O. A. Svitich
author_facet	O. A. Ponasenko L. V. Gankovskaya O. A. Svitich
author_sort	O. A. Ponasenko
title	THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY
title_short	THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY
title_full	THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY
title_fullStr	THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY
title_full_unstemmed	THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY
title_sort	role of the heat shock protein 70 in the pathogenesis of cardiovascular pathology
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/77815d11da104f57afcf87618f49599f
work_keys_str_mv	AT oaponasenko theroleoftheheatshockprotein70inthepathogenesisofcardiovascularpathology AT lvgankovskaya theroleoftheheatshockprotein70inthepathogenesisofcardiovascularpathology AT oasvitich theroleoftheheatshockprotein70inthepathogenesisofcardiovascularpathology AT oaponasenko roleoftheheatshockprotein70inthepathogenesisofcardiovascularpathology AT lvgankovskaya roleoftheheatshockprotein70inthepathogenesisofcardiovascularpathology AT oasvitich roleoftheheatshockprotein70inthepathogenesisofcardiovascularpathology
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THE ROLE OF THE HEAT SHOCK PROTEIN 70 IN THE PATHOGENESIS OF CARDIOVASCULAR PATHOLOGY

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