Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote

Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-induced pain and tissue damage in vivo.

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Autores principales:	Man-Tat Lau, John Manion, Jamie B. Littleboy, Lisa Oyston, Thang M. Khuong, Qiao-Ping Wang, David T. Nguyen, Daniel Hesselson, Jamie E. Seymour, G. Gregory Neely
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7783b05d2b904dac8b8436b3b11b2579
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spelling	oai:doaj.org-article:7783b05d2b904dac8b8436b3b11b25792021-12-02T17:01:28ZMolecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote10.1038/s41467-019-09681-12041-1723https://doaj.org/article/7783b05d2b904dac8b8436b3b11b25792019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09681-1https://doaj.org/toc/2041-1723Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-induced pain and tissue damage in vivo.Man-Tat LauJohn ManionJamie B. LittleboyLisa OystonThang M. KhuongQiao-Ping WangDavid T. NguyenDaniel HesselsonJamie E. SeymourG. Gregory NeelyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Man-Tat Lau John Manion Jamie B. Littleboy Lisa Oyston Thang M. Khuong Qiao-Ping Wang David T. Nguyen Daniel Hesselson Jamie E. Seymour G. Gregory Neely Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
description	Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-induced pain and tissue damage in vivo.
format	article
author	Man-Tat Lau John Manion Jamie B. Littleboy Lisa Oyston Thang M. Khuong Qiao-Ping Wang David T. Nguyen Daniel Hesselson Jamie E. Seymour G. Gregory Neely
author_facet	Man-Tat Lau John Manion Jamie B. Littleboy Lisa Oyston Thang M. Khuong Qiao-Ping Wang David T. Nguyen Daniel Hesselson Jamie E. Seymour G. Gregory Neely
author_sort	Man-Tat Lau
title	Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
title_short	Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
title_full	Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
title_fullStr	Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
title_full_unstemmed	Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
title_sort	molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7783b05d2b904dac8b8436b3b11b2579
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Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote

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