An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.

Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prosta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michał Kiciński, Jaco Vangronsveld, Tim S Nawrot
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7786b48fea7b4a3e9885e82fcadd23de
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7786b48fea7b4a3e9885e82fcadd23de
record_format	dspace
spelling	oai:doaj.org-article:7786b48fea7b4a3e9885e82fcadd23de2021-11-18T07:35:20ZAn epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.1932-620310.1371/journal.pone.0027130https://doaj.org/article/7786b48fea7b4a3e9885e82fcadd23de2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073129/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37-4.15), and for those with affected father 2.35 times (CI:2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21-3.74), than in men aged 65 and older (RR:1.92, CI:1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6-63.5%) for men at all ages, 65.2% (CI:57.7-71.4%) for men younger than 65 and 47.9% (CI:37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).Michał KicińskiJaco VangronsveldTim S NawrotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e27130 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michał Kiciński Jaco Vangronsveld Tim S Nawrot An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
description	Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37-4.15), and for those with affected father 2.35 times (CI:2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21-3.74), than in men aged 65 and older (RR:1.92, CI:1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6-63.5%) for men at all ages, 65.2% (CI:57.7-71.4%) for men younger than 65 and 47.9% (CI:37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).
format	article
author	Michał Kiciński Jaco Vangronsveld Tim S Nawrot
author_facet	Michał Kiciński Jaco Vangronsveld Tim S Nawrot
author_sort	Michał Kiciński
title	An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
title_short	An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
title_full	An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
title_fullStr	An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
title_full_unstemmed	An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
title_sort	epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/7786b48fea7b4a3e9885e82fcadd23de
work_keys_str_mv	AT michałkicinski anepidemiologicalreappraisalofthefamilialaggregationofprostatecancerametaanalysis AT jacovangronsveld anepidemiologicalreappraisalofthefamilialaggregationofprostatecancerametaanalysis AT timsnawrot anepidemiologicalreappraisalofthefamilialaggregationofprostatecancerametaanalysis AT michałkicinski epidemiologicalreappraisalofthefamilialaggregationofprostatecancerametaanalysis AT jacovangronsveld epidemiologicalreappraisalofthefamilialaggregationofprostatecancerametaanalysis AT timsnawrot epidemiologicalreappraisalofthefamilialaggregationofprostatecancerametaanalysis
_version_	1718423229432856576

An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.

Ejemplares similares