Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK

Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK

Yuri S Astakhov, Sergei Y Astakhov, Alla B Lisochkina University Department of Ophthalmology, State Educational Establishment of Higher Professional Education, Saint Petersburg Pavlov State Medical University and of the Federal Service for Surveillance of Healthcare and Social Development of the Rus...

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Autores principales: Astakhov YS, Astakhov SY, Lisochkina AB
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/778c676c341f464f908e8d30f95092f4
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spelling oai:doaj.org-article:778c676c341f464f908e8d30f95092f42021-12-02T07:02:42ZAssessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK1177-54671177-5483https://doaj.org/article/778c676c341f464f908e8d30f95092f42013-12-01T00:00:00Zhttp://www.dovepress.com/assessment-of-dry-eye-signs-and-symptoms-and-ocular-tolerance-of-a-pre-a15240https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yuri S Astakhov, Sergei Y Astakhov, Alla B Lisochkina University Department of Ophthalmology, State Educational Establishment of Higher Professional Education, Saint Petersburg Pavlov State Medical University and of the Federal Service for Surveillance of Healthcare and Social Development of the Russian Federation, St Petersburg, Russia Abstract: Laser-assisted in situ keratomileusis (LASIK) is commonly used to correct refractive defects. The procedure frequently results in dry eye symptoms, usually of short but sometimes longer duration. This study was designed to assess dry eye and ocular tolerability after LASIK in patients treated with a preservative-free lacrimal substitute (Hylabak®) or preserved lacrimal substitute (Systane®). In a single-center, investigator-masked, prospective, noninferiority, clinical study, patients undergoing LASIK surgery were randomized to receive Hylabak or Systane eye drops (one drop in each eye four times daily for 3 months). Fluorescein test scores were the primary efficacy variable and were similar on day 1 (mean 0.26 and 0.28 for Hylabak and Systane, respectively). At the final visit (day 84 ± 3) the fluorescein scores had improved to 0.11 and 0.04, respectively. The difference was not significant and thus noninferiority was established. A trend of more rapid improvement in the Hylabak group was evident. Both treatments were well tolerated and there were no serious adverse events, discontinuations for adverse events or other safety-related reasons, and no systemic adverse events. The results suggest that Hylabak is not less effective than Systane in reducing the symptoms of dry eye after LASIK surgery. Keywords: dry eye, laser-assisted in situ keratomileusis, hyaluronateAstakhov YSAstakhov SYLisochkina ABDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2289-2297 (2013)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Astakhov YS
Astakhov SY
Lisochkina AB
Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK
description Yuri S Astakhov, Sergei Y Astakhov, Alla B Lisochkina University Department of Ophthalmology, State Educational Establishment of Higher Professional Education, Saint Petersburg Pavlov State Medical University and of the Federal Service for Surveillance of Healthcare and Social Development of the Russian Federation, St Petersburg, Russia Abstract: Laser-assisted in situ keratomileusis (LASIK) is commonly used to correct refractive defects. The procedure frequently results in dry eye symptoms, usually of short but sometimes longer duration. This study was designed to assess dry eye and ocular tolerability after LASIK in patients treated with a preservative-free lacrimal substitute (Hylabak®) or preserved lacrimal substitute (Systane®). In a single-center, investigator-masked, prospective, noninferiority, clinical study, patients undergoing LASIK surgery were randomized to receive Hylabak or Systane eye drops (one drop in each eye four times daily for 3 months). Fluorescein test scores were the primary efficacy variable and were similar on day 1 (mean 0.26 and 0.28 for Hylabak and Systane, respectively). At the final visit (day 84 ± 3) the fluorescein scores had improved to 0.11 and 0.04, respectively. The difference was not significant and thus noninferiority was established. A trend of more rapid improvement in the Hylabak group was evident. Both treatments were well tolerated and there were no serious adverse events, discontinuations for adverse events or other safety-related reasons, and no systemic adverse events. The results suggest that Hylabak is not less effective than Systane in reducing the symptoms of dry eye after LASIK surgery. Keywords: dry eye, laser-assisted in situ keratomileusis, hyaluronate
format article
author Astakhov YS
Astakhov SY
Lisochkina AB
author_facet Astakhov YS
Astakhov SY
Lisochkina AB
author_sort Astakhov YS
title Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK
title_short Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK
title_full Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK
title_fullStr Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK
title_full_unstemmed Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK
title_sort assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (hylabak®) versus a preserved lacrimal substitute (systane®) used for 3 months in patients after lasik
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/778c676c341f464f908e8d30f95092f4
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AT astakhovsy assessmentofdryeyesignsandsymptomsandoculartoleranceofapreservativefreelacrimalsubstitutehylabakregversusapreservedlacrimalsubstitutesystaneregusedfor3monthsinpatientsafterlasik
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