X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model

Abstract The aim of this study was to evaluate whether diagnosing pulmonary fibrosis with projection radiography can be improved by using X-ray dark-field radiograms. Pulmonary X-ray transmission and dark-field images of C57Bl/6N mice, either treated with bleomycin to induce pulmonary fibrosis or PB...

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Autores principales:	Katharina Hellbach, Andre Yaroshenko, Konstantin Willer, Thomas M. Conlon, Margarita B. Braunagel, Sigrid Auweter, Ali Ö. Yildirim, Oliver Eickelberg, Franz Pfeiffer, Maximilian F. Reiser, Felix G. Meinel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/778d35500b7649488a48dac9477da47e
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spelling	oai:doaj.org-article:778d35500b7649488a48dac9477da47e2021-12-02T16:06:04ZX-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model10.1038/s41598-017-00475-32045-2322https://doaj.org/article/778d35500b7649488a48dac9477da47e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00475-3https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate whether diagnosing pulmonary fibrosis with projection radiography can be improved by using X-ray dark-field radiograms. Pulmonary X-ray transmission and dark-field images of C57Bl/6N mice, either treated with bleomycin to induce pulmonary fibrosis or PBS to serve as controls, were acquired with a prototype grating-based small-animal scanner. Two blinded readers, both experienced radiologists and familiar with dark-field imaging, had to assess dark-field and transmission images for the absence or presence of fibrosis. Furthermore readers were asked to grade their stage of diagnostic confidence. Histological evaluation of the lungs served as the standard of reference in this study. Both readers showed a notably higher diagnostic confidence when analyzing the dark-field radiographs (p < 0.001). Diagnostic accuracy improved significantly when evaluating the lungs in dark-field images alone (p = 0.02) or in combination with transmission images (p = 0.01) compared to sole analysis of absorption images. Interreader agreement improved from good when assessing only transmission images to excellent when analyzing dark-field images alone or in combination with transmission images. Adding dark-field images to conventional transmission images in a murine model of pulmonary fibrosis leads to an improved diagnosis of this disease on chest radiographs.Katharina HellbachAndre YaroshenkoKonstantin WillerThomas M. ConlonMargarita B. BraunagelSigrid AuweterAli Ö. YildirimOliver EickelbergFranz PfeifferMaximilian F. ReiserFelix G. MeinelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katharina Hellbach Andre Yaroshenko Konstantin Willer Thomas M. Conlon Margarita B. Braunagel Sigrid Auweter Ali Ö. Yildirim Oliver Eickelberg Franz Pfeiffer Maximilian F. Reiser Felix G. Meinel X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
description	Abstract The aim of this study was to evaluate whether diagnosing pulmonary fibrosis with projection radiography can be improved by using X-ray dark-field radiograms. Pulmonary X-ray transmission and dark-field images of C57Bl/6N mice, either treated with bleomycin to induce pulmonary fibrosis or PBS to serve as controls, were acquired with a prototype grating-based small-animal scanner. Two blinded readers, both experienced radiologists and familiar with dark-field imaging, had to assess dark-field and transmission images for the absence or presence of fibrosis. Furthermore readers were asked to grade their stage of diagnostic confidence. Histological evaluation of the lungs served as the standard of reference in this study. Both readers showed a notably higher diagnostic confidence when analyzing the dark-field radiographs (p < 0.001). Diagnostic accuracy improved significantly when evaluating the lungs in dark-field images alone (p = 0.02) or in combination with transmission images (p = 0.01) compared to sole analysis of absorption images. Interreader agreement improved from good when assessing only transmission images to excellent when analyzing dark-field images alone or in combination with transmission images. Adding dark-field images to conventional transmission images in a murine model of pulmonary fibrosis leads to an improved diagnosis of this disease on chest radiographs.
format	article
author	Katharina Hellbach Andre Yaroshenko Konstantin Willer Thomas M. Conlon Margarita B. Braunagel Sigrid Auweter Ali Ö. Yildirim Oliver Eickelberg Franz Pfeiffer Maximilian F. Reiser Felix G. Meinel
author_facet	Katharina Hellbach Andre Yaroshenko Konstantin Willer Thomas M. Conlon Margarita B. Braunagel Sigrid Auweter Ali Ö. Yildirim Oliver Eickelberg Franz Pfeiffer Maximilian F. Reiser Felix G. Meinel
author_sort	Katharina Hellbach
title	X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
title_short	X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
title_full	X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
title_fullStr	X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
title_full_unstemmed	X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
title_sort	x-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/778d35500b7649488a48dac9477da47e
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X-ray dark-field radiography facilitates the diagnosis of pulmonary fibrosis in a mouse model

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