The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation

Aim. To assess the relationship of rs5918 ITGB3, rs1126643 ITGA2 and rs5985 F13A1 polymorphic loci with the risk for preeclampsia (PE) in pregnant women with fetal growth retardation (FGR). Materials and methods. The study included 272 pregnant women, of which 76 had a combination of PE and FGR a...

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Autores principales:	Oleg V. Golovchenko, Irina V. Ponomarenko, Mikhail I. Churnosov
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	preeclampsia fetal growth retardation polymorphism itgb3 associations Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/778daecc338f477f99516f3367ff2368
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spelling	oai:doaj.org-article:778daecc338f477f99516f3367ff23682021-12-02T19:22:24ZThe rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation2079-56962079-583110.26442/20795696.2021.4.200863https://doaj.org/article/778daecc338f477f99516f3367ff23682021-09-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/80267/pdfhttps://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To assess the relationship of rs5918 ITGB3, rs1126643 ITGA2 and rs5985 F13A1 polymorphic loci with the risk for preeclampsia (PE) in pregnant women with fetal growth retardation (FGR). Materials and methods. The study included 272 pregnant women, of which 76 had a combination of PE and FGR and 196 had FGR. In the studied groups, genetic testing was carried out for three polymorphic loci of candidate genes for hereditary thrombophilia (rs5918 ITGB3, rs1126643 ITGA2, and rs5985 F13A1). Results. The rs5918 genetic variant in the ITGB3 gene is associated with the development of PE in pregnant women with FGR: C allele of rs5918 ITGB3 increases the risk for this complication of pregnancy by 1,8 times (OR 1.761.77, p0.036, pperm0.038). The rs5918 polymorphism determines an increase in the affinity of DNA motifs for seven transcription factors (BDP1, ELF1, IRF, NRSF, Pax-5, Sp1, and Zfx), is a missense mutation and causes the Leu59Pro amino acid substitution in the 3 subunit of integrin, is multidirectionally associated with the expression of five genes (EFCAB13, TBKBP1, NPEPPS, MRPL45P2, THCAT158) and alternative splicing of two genes (EFCAB13, MRPL45P2), is located in the region of functionally important DNA regions (promoters and enhancers) in cell cultures and organs which are pathogenetically important for the formation of PE and FGR. Conclusion. The rs5918 polymorphism in the ITGB3 gene increases the risk for PE in pregnant women with FGR.Oleg V. GolovchenkoIrina V. PonomarenkoMikhail I. ChurnosovIP Berlin A.V. articlepreeclampsiafetal growth retardationpolymorphismitgb3associationsGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 4, Pp 330-334 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	preeclampsia fetal growth retardation polymorphism itgb3 associations Gynecology and obstetrics RG1-991
spellingShingle	preeclampsia fetal growth retardation polymorphism itgb3 associations Gynecology and obstetrics RG1-991 Oleg V. Golovchenko Irina V. Ponomarenko Mikhail I. Churnosov The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
description	Aim. To assess the relationship of rs5918 ITGB3, rs1126643 ITGA2 and rs5985 F13A1 polymorphic loci with the risk for preeclampsia (PE) in pregnant women with fetal growth retardation (FGR). Materials and methods. The study included 272 pregnant women, of which 76 had a combination of PE and FGR and 196 had FGR. In the studied groups, genetic testing was carried out for three polymorphic loci of candidate genes for hereditary thrombophilia (rs5918 ITGB3, rs1126643 ITGA2, and rs5985 F13A1). Results. The rs5918 genetic variant in the ITGB3 gene is associated with the development of PE in pregnant women with FGR: C allele of rs5918 ITGB3 increases the risk for this complication of pregnancy by 1,8 times (OR 1.761.77, p0.036, pperm0.038). The rs5918 polymorphism determines an increase in the affinity of DNA motifs for seven transcription factors (BDP1, ELF1, IRF, NRSF, Pax-5, Sp1, and Zfx), is a missense mutation and causes the Leu59Pro amino acid substitution in the 3 subunit of integrin, is multidirectionally associated with the expression of five genes (EFCAB13, TBKBP1, NPEPPS, MRPL45P2, THCAT158) and alternative splicing of two genes (EFCAB13, MRPL45P2), is located in the region of functionally important DNA regions (promoters and enhancers) in cell cultures and organs which are pathogenetically important for the formation of PE and FGR. Conclusion. The rs5918 polymorphism in the ITGB3 gene increases the risk for PE in pregnant women with FGR.
format	article
author	Oleg V. Golovchenko Irina V. Ponomarenko Mikhail I. Churnosov
author_facet	Oleg V. Golovchenko Irina V. Ponomarenko Mikhail I. Churnosov
author_sort	Oleg V. Golovchenko
title	The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
title_short	The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
title_full	The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
title_fullStr	The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
title_full_unstemmed	The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
title_sort	rs5918 polymorphism in the <i>itgb3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/778daecc338f477f99516f3367ff2368
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The rs5918 polymorphism in the <i>ITGB3</i> gene increases the risk for preeclampsia in pregnant women with fetal growth retardation

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