The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test

Gail TorkildsenAndover Eye Associates, Andover, MA, USAObjective: The purpose of the current study was to evaluate the effects of two marketed ocular lubricants on the visual decay in dry eye patients using the Inter-blink interval Visual Acuity Decay (IVAD) test.Methods: This controlled, randomized...

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Autor principal:	Gail Torkildsen
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/778f943caa9844d2aacd2ed1a9e7c80a
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spelling	oai:doaj.org-article:778f943caa9844d2aacd2ed1a9e7c80a2021-12-02T07:12:20ZThe effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test1177-54671177-5483https://doaj.org/article/778f943caa9844d2aacd2ed1a9e7c80a2009-09-01T00:00:00Zhttp://www.dovepress.com/the-effects-of-lubricant-eye-drops-on-visual-function-as-measured-by-t-a3536https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Gail TorkildsenAndover Eye Associates, Andover, MA, USAObjective: The purpose of the current study was to evaluate the effects of two marketed ocular lubricants on the visual decay in dry eye patients using the Inter-blink interval Visual Acuity Decay (IVAD) test.Methods: This controlled, randomized, double-masked crossover study compared the effects of a polyethylene glycol/propylene glycol-based (PEG/PG) tear and a carboxymethylcellulose sodium (CMC)/glycerin tear on the visual acuity decay between blinks of dry eye patients. At visit 1 (Day 0), baseline IVAD measurements were recorded prior to instillation of a single drop of randomized study medication. IVAD testing was repeated at 15-, 45-, and 90-minutes post-instillation. Reading rate and functional blink rate were also evaluated. At the second visit (Day 7 &plusmn; 3), study procedures were repeated using crossover treatment.Results: Forty-eight (48) subjects with dry eye (61.1 &plusmn; 14.8 years old, 79.2% female, 95.8% white) completed the study. Treatment with the PEG/PG-based tear demonstrated statistically significantly longer time to one-line loss of best-corrected visual acuity (BCVA) as determined by the IVAD test at 90 minutes post-instillation compared to the CMC/glycerin tear (P = 0.0365). Measurements of median time at BCVA, reading rate, and functional blink rate were similar for both treatments. Both formulations were well tolerated in the population studied.Conclusions: Treatment with the PEG/PG-based tear demonstrated statistically significant improved maintenance of visual acuity between blinks at 90 minutes post-instillation compared to the CMC/glycerin tear. This is the first study to demonstrate the ability of an artificial tear to extend visual acuity maintenance between blinks, as measured by the IVAD test.Keywords: dry eye, visual function, artificial tears, ocular lubricant Gail TorkildsenDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 501-506 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Gail Torkildsen The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test
description	Gail TorkildsenAndover Eye Associates, Andover, MA, USAObjective: The purpose of the current study was to evaluate the effects of two marketed ocular lubricants on the visual decay in dry eye patients using the Inter-blink interval Visual Acuity Decay (IVAD) test.Methods: This controlled, randomized, double-masked crossover study compared the effects of a polyethylene glycol/propylene glycol-based (PEG/PG) tear and a carboxymethylcellulose sodium (CMC)/glycerin tear on the visual acuity decay between blinks of dry eye patients. At visit 1 (Day 0), baseline IVAD measurements were recorded prior to instillation of a single drop of randomized study medication. IVAD testing was repeated at 15-, 45-, and 90-minutes post-instillation. Reading rate and functional blink rate were also evaluated. At the second visit (Day 7 &plusmn; 3), study procedures were repeated using crossover treatment.Results: Forty-eight (48) subjects with dry eye (61.1 &plusmn; 14.8 years old, 79.2% female, 95.8% white) completed the study. Treatment with the PEG/PG-based tear demonstrated statistically significantly longer time to one-line loss of best-corrected visual acuity (BCVA) as determined by the IVAD test at 90 minutes post-instillation compared to the CMC/glycerin tear (P = 0.0365). Measurements of median time at BCVA, reading rate, and functional blink rate were similar for both treatments. Both formulations were well tolerated in the population studied.Conclusions: Treatment with the PEG/PG-based tear demonstrated statistically significant improved maintenance of visual acuity between blinks at 90 minutes post-instillation compared to the CMC/glycerin tear. This is the first study to demonstrate the ability of an artificial tear to extend visual acuity maintenance between blinks, as measured by the IVAD test.Keywords: dry eye, visual function, artificial tears, ocular lubricant
format	article
author	Gail Torkildsen
author_facet	Gail Torkildsen
author_sort	Gail Torkildsen
title	The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test
title_short	The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test
title_full	The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test
title_fullStr	The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test
title_full_unstemmed	The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test
title_sort	effects of lubricant eye drops on visual function as measured by the inter-blink interval visual acuity decay test
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/778f943caa9844d2aacd2ed1a9e7c80a
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The effects of lubricant eye drops on visual function as measured by the Inter-blink interval Visual Acuity Decay test

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