Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study

Jennifer Murdock,1,* Mohamed S Sayed,1,* Mehdi Tavakoli,1,2 Dimitra M Portaliou,1 Wendy W Lee1 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti Universi...

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Autores principales:	Murdock J, Sayed MS, Tavakoli M, Portaliou DM, Lee WW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	blepharoplasty eyelid surgery surgical scar Lumiere Eye Cream wound healing Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/77904263b95148659bccd02407cac193
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spelling	oai:doaj.org-article:77904263b95148659bccd02407cac1932021-12-02T02:47:18ZSafety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study1177-5483https://doaj.org/article/77904263b95148659bccd02407cac1932016-06-01T00:00:00Zhttps://www.dovepress.com/safety-and-efficacy-of-a-growth-factor-and-cytokine-containing-topical-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jennifer Murdock,1,* Mohamed S Sayed,1,* Mehdi Tavakoli,1,2 Dimitra M Portaliou,1 Wendy W Lee1 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran *These authors contributed equally to this work Purpose: To evaluate the efficacy and safety of a topical product containing a mixture of growth factors and cytokines on the incision scar following upper eyelid blepharoplasty. Methods: This is a prospective, single-blinded, and split-face study on patients who underwent bilateral upper eyelid blepharoplasty. Two weeks after surgery, one eye of each subject was randomized to receive Lumière Bio-Restorative Eye Cream on one eyelid incision for 12 weeks and no treatment on the other eyelid. Subjects returned at the postoperative weeks 6, 10, and 14. At each visit, patients and the investigator (who was blinded to the treated eyelid) evaluated the scar through specified questionnaires. Results: A total of 20 subjects with a mean age of 66.3±9.2 years completed the study. Minor side effects were noted in three subjects. At all-time points, all subjects thought eyelids treated with Lumière had a better scar and overall appearance than fellow eyelids (P<0.5); and 60% of patients strongly encouraged others to use the product. The investigator assessment of erythema and pigmentation revealed less erythema and pigmentation in treated eyes at the weeks 6 and 10, although the difference was statistically insignificant. Investigator assessment also revealed a better scar appearance at week 10 in treated eyes (P=0.04). All evaluation parameters were similar in both eyes at the last visit. Conclusion: Lumière eye cream shows an excellent safety profile and minimal effects on features of the incision scar following upper lid blepharoplasty. It may hasten the wound healing process considering the higher outcomes at the first weeks of application. Keywords: processed skin cell proteins, PSP®, skin cream, eye cream, eyelid surgery, LumièreMurdock JSayed MSTavakoli MPortaliou DMLee WWDove Medical Pressarticleblepharoplastyeyelid surgerysurgical scarLumiere Eye Creamwound healingOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1223-1228 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	blepharoplasty eyelid surgery surgical scar Lumiere Eye Cream wound healing Ophthalmology RE1-994
spellingShingle	blepharoplasty eyelid surgery surgical scar Lumiere Eye Cream wound healing Ophthalmology RE1-994 Murdock J Sayed MS Tavakoli M Portaliou DM Lee WW Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
description	Jennifer Murdock,1,* Mohamed S Sayed,1,* Mehdi Tavakoli,1,2 Dimitra M Portaliou,1 Wendy W Lee1 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran *These authors contributed equally to this work Purpose: To evaluate the efficacy and safety of a topical product containing a mixture of growth factors and cytokines on the incision scar following upper eyelid blepharoplasty. Methods: This is a prospective, single-blinded, and split-face study on patients who underwent bilateral upper eyelid blepharoplasty. Two weeks after surgery, one eye of each subject was randomized to receive Lumière Bio-Restorative Eye Cream on one eyelid incision for 12 weeks and no treatment on the other eyelid. Subjects returned at the postoperative weeks 6, 10, and 14. At each visit, patients and the investigator (who was blinded to the treated eyelid) evaluated the scar through specified questionnaires. Results: A total of 20 subjects with a mean age of 66.3±9.2 years completed the study. Minor side effects were noted in three subjects. At all-time points, all subjects thought eyelids treated with Lumière had a better scar and overall appearance than fellow eyelids (P<0.5); and 60% of patients strongly encouraged others to use the product. The investigator assessment of erythema and pigmentation revealed less erythema and pigmentation in treated eyes at the weeks 6 and 10, although the difference was statistically insignificant. Investigator assessment also revealed a better scar appearance at week 10 in treated eyes (P=0.04). All evaluation parameters were similar in both eyes at the last visit. Conclusion: Lumière eye cream shows an excellent safety profile and minimal effects on features of the incision scar following upper lid blepharoplasty. It may hasten the wound healing process considering the higher outcomes at the first weeks of application. Keywords: processed skin cell proteins, PSP®, skin cream, eye cream, eyelid surgery, Lumière
format	article
author	Murdock J Sayed MS Tavakoli M Portaliou DM Lee WW
author_facet	Murdock J Sayed MS Tavakoli M Portaliou DM Lee WW
author_sort	Murdock J
title	Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
title_short	Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
title_full	Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
title_fullStr	Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
title_full_unstemmed	Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
title_sort	safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/77904263b95148659bccd02407cac193
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Safety and efficacy of a growth factor and cytokine-containing topical product in wound healing and incision scar management after upper eyelid blepharoplasty: a prospective split-face study

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