RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE

Objective: To determine the relation of response assessment and outcome of B cell non-Hodgkinlymphoma so we can minimize utilization of our resources. Study Design: Retrospective observational study. Place and Duration of Study: Pediatric Oncology Department, Shaukat khanum Memorial Cancer Hos...

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Autores principales:	Palwasha Rehman, Rabia Muhammad Wali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	b cell non-hodgkin children computed tomography scan response evaluation Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/77923cda0e77456084c2b66ed319a0e9
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spelling	oai:doaj.org-article:77923cda0e77456084c2b66ed319a0e92021-12-02T17:20:37ZRESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE0030-96482411-8842https://doaj.org/article/77923cda0e77456084c2b66ed319a0e92020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5573https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the relation of response assessment and outcome of B cell non-Hodgkinlymphoma so we can minimize utilization of our resources. Study Design: Retrospective observational study. Place and Duration of Study: Pediatric Oncology Department, Shaukat khanum Memorial Cancer Hospital and Research Centre, from Jan 2013 to Dec 2016. Methodology: Patients from the age of 1 till 18 years presented at Shaukat khanum hospital were included in the study. Patients were staged as per St. Jude staging system and response assessment done as per French-American British (FAB) Lymphome Malins De Burkitt (LMB) protocol. Results: Total 247 patients diagnosed with B cell Non-Hodgkin Lymphoma were included. When the interim scans were compared with the end of treatment assessment, 139 (82.2%) patients (n=169) had achieved complete morphological remission on the re-evaluation scans, 138 patients (86.2%) among them were in remission at end of treatment where as 01 patient had relapse disease. The interim disease re-evaluation scan is predictive of end of treatment response with sensitivity of 86.8%, specificity of 88.9% (p-value <0.005) Conclusion: The patients who achieved rapid response on re-assessment scans have good outcomes. We recommend that in future patient’s with complete response on interim scans to be followed with ultrasonography or clinical examination to minimize expenditures and radiation exposure.Palwasha RehmanRabia Muhammad WaliArmy Medical College Rawalpindiarticleb cell non-hodgkinchildrencomputed tomography scanresponse evaluationMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1402-1407 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	b cell non-hodgkin children computed tomography scan response evaluation Medicine R Medicine (General) R5-920
spellingShingle	b cell non-hodgkin children computed tomography scan response evaluation Medicine R Medicine (General) R5-920 Palwasha Rehman Rabia Muhammad Wali RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE
description	Objective: To determine the relation of response assessment and outcome of B cell non-Hodgkinlymphoma so we can minimize utilization of our resources. Study Design: Retrospective observational study. Place and Duration of Study: Pediatric Oncology Department, Shaukat khanum Memorial Cancer Hospital and Research Centre, from Jan 2013 to Dec 2016. Methodology: Patients from the age of 1 till 18 years presented at Shaukat khanum hospital were included in the study. Patients were staged as per St. Jude staging system and response assessment done as per French-American British (FAB) Lymphome Malins De Burkitt (LMB) protocol. Results: Total 247 patients diagnosed with B cell Non-Hodgkin Lymphoma were included. When the interim scans were compared with the end of treatment assessment, 139 (82.2%) patients (n=169) had achieved complete morphological remission on the re-evaluation scans, 138 patients (86.2%) among them were in remission at end of treatment where as 01 patient had relapse disease. The interim disease re-evaluation scan is predictive of end of treatment response with sensitivity of 86.8%, specificity of 88.9% (p-value <0.005) Conclusion: The patients who achieved rapid response on re-assessment scans have good outcomes. We recommend that in future patient’s with complete response on interim scans to be followed with ultrasonography or clinical examination to minimize expenditures and radiation exposure.
format	article
author	Palwasha Rehman Rabia Muhammad Wali
author_facet	Palwasha Rehman Rabia Muhammad Wali
author_sort	Palwasha Rehman
title	RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE
title_short	RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE
title_full	RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE
title_fullStr	RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE
title_full_unstemmed	RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE
title_sort	response assessment and outcomes in pediatric b cell non-hodgkin lymphoma: our experience at shaukat khanum memorial cancer hospital and research centre
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/77923cda0e77456084c2b66ed319a0e9
work_keys_str_mv	AT palwasharehman responseassessmentandoutcomesinpediatricbcellnonhodgkinlymphomaourexperienceatshaukatkhanummemorialcancerhospitalandresearchcentre AT rabiamuhammadwali responseassessmentandoutcomesinpediatricbcellnonhodgkinlymphomaourexperienceatshaukatkhanummemorialcancerhospitalandresearchcentre
_version_	1718381033859055616

RESPONSE ASSESSMENT AND OUTCOMES IN PEDIATRIC B CELL NON-HODGKIN LYMPHOMA: OUR EXPERIENCE AT SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE

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