Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering

The final biochemical and mechanical performance of an implant or scaffold are defined by its structure, as well as the raw materials and processing conditions used during its fabrication. Electrospinning and Additive Manufacturing (AM) are two contrasting processing technologies that have gained po...

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Autores principales:	James A. Smith, Elisa Mele
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	electrospininng tissue engineering additive manufactuing hybrid scaffolds nanofibers Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/7794544240dd4a65916e6b14626e343b
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spelling	oai:doaj.org-article:7794544240dd4a65916e6b14626e343b2021-12-01T19:29:17ZElectrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering2296-418510.3389/fbioe.2021.674738https://doaj.org/article/7794544240dd4a65916e6b14626e343b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.674738/fullhttps://doaj.org/toc/2296-4185The final biochemical and mechanical performance of an implant or scaffold are defined by its structure, as well as the raw materials and processing conditions used during its fabrication. Electrospinning and Additive Manufacturing (AM) are two contrasting processing technologies that have gained popularity amongst the fields of medical research i.e., tissue engineering, implant design, drug delivery. Electrospinning technology is favored for its ability to produce micro- to nanometer fibers from polymer solutions and melts, of which, the dimensions, alignment, porosity, and chemical composition are easily manipulatable to the desired application. AM, on the other hand, offers unrivalled levels of geometrical freedom, allowing highly complex components (i.e., patient-specific) to be built inexpensively within 24 hours. Hence, adopting both technologies together appears to be a progressive step in pursuit of scaffolds that better match the natural architecture of human tissues. Here, we present recent insights into the advances on hybrid scaffolds produced by combining electrospinning (melt electrospinning excluded) and AM, specifically multi-layered architectures consisting of alternating fibers and AM elements, and bioinks reinforced with fibers prior to AM. We discuss how cellular behavior (attachment, migration, and differentiation) is influenced by the co-existence of these micro- and nano-features.James A. SmithElisa MeleFrontiers Media S.A.articleelectrospininngtissue engineeringadditive manufactuinghybrid scaffoldsnanofibersBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrospininng tissue engineering additive manufactuing hybrid scaffolds nanofibers Biotechnology TP248.13-248.65
spellingShingle	electrospininng tissue engineering additive manufactuing hybrid scaffolds nanofibers Biotechnology TP248.13-248.65 James A. Smith Elisa Mele Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering
description	The final biochemical and mechanical performance of an implant or scaffold are defined by its structure, as well as the raw materials and processing conditions used during its fabrication. Electrospinning and Additive Manufacturing (AM) are two contrasting processing technologies that have gained popularity amongst the fields of medical research i.e., tissue engineering, implant design, drug delivery. Electrospinning technology is favored for its ability to produce micro- to nanometer fibers from polymer solutions and melts, of which, the dimensions, alignment, porosity, and chemical composition are easily manipulatable to the desired application. AM, on the other hand, offers unrivalled levels of geometrical freedom, allowing highly complex components (i.e., patient-specific) to be built inexpensively within 24 hours. Hence, adopting both technologies together appears to be a progressive step in pursuit of scaffolds that better match the natural architecture of human tissues. Here, we present recent insights into the advances on hybrid scaffolds produced by combining electrospinning (melt electrospinning excluded) and AM, specifically multi-layered architectures consisting of alternating fibers and AM elements, and bioinks reinforced with fibers prior to AM. We discuss how cellular behavior (attachment, migration, and differentiation) is influenced by the co-existence of these micro- and nano-features.
format	article
author	James A. Smith Elisa Mele
author_facet	James A. Smith Elisa Mele
author_sort	James A. Smith
title	Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering
title_short	Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering
title_full	Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering
title_fullStr	Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering
title_full_unstemmed	Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering
title_sort	electrospinning and additive manufacturing: adding three-dimensionality to electrospun scaffolds for tissue engineering
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7794544240dd4a65916e6b14626e343b
work_keys_str_mv	AT jamesasmith electrospinningandadditivemanufacturingaddingthreedimensionalitytoelectrospunscaffoldsfortissueengineering AT elisamele electrospinningandadditivemanufacturingaddingthreedimensionalitytoelectrospunscaffoldsfortissueengineering
_version_	1718404638829445120

Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering

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