Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in <named-content content-type="genus-species">Plasmodium falciparum</named-content> through the Action of Protein Kinase G
ABSTRACT We used a sensitization approach that involves replacement of the gatekeeper residue in a protein kinase with one with a different side chain. The activity of the enzyme with a bulky gatekeeper residue, such as methionine, cannot be inhibited using bumped kinase inhibitors (BKIs). Here, we...
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Autores principales: | Abhisheka Bansal, Kayode K. Ojo, Jianbing Mu, Dustin J. Maly, Wesley C. Van Voorhis, Louis H. Miller |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2016
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Materias: | |
Acceso en línea: | https://doaj.org/article/77983dde2f9846ecaed7044b4deeda32 |
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