The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.

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Detalles Bibliográficos
Autores principales: C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c
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Descripción
Sumario:The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.

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