The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.

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Autores principales:	C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c
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spelling	oai:doaj.org-article:7798914f5f094e87a7d8b776f5a7230c2021-12-02T17:33:10ZThe transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature10.1038/s41467-019-12897-w2041-1723https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12897-whttps://doaj.org/toc/2041-1723The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.C. PeghaireN. P. DuftonM. LangI. I. Salles-CrawleyJ. AhnströmV. KalnaC. RaimondiC. PericleousL. InuabasiR. KiselevaV. R. MuzykantovJ. C. MasonG. M. BirdseyA. M. RandiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. Peghaire N. P. Dufton M. Lang I. I. Salles-Crawley J. Ahnström V. Kalna C. Raimondi C. Pericleous L. Inuabasi R. Kiseleva V. R. Muzykantov J. C. Mason G. M. Birdsey A. M. Randi The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
description	The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.
format	article
author	C. Peghaire N. P. Dufton M. Lang I. I. Salles-Crawley J. Ahnström V. Kalna C. Raimondi C. Pericleous L. Inuabasi R. Kiseleva V. R. Muzykantov J. C. Mason G. M. Birdsey A. M. Randi
author_facet	C. Peghaire N. P. Dufton M. Lang I. I. Salles-Crawley J. Ahnström V. Kalna C. Raimondi C. Pericleous L. Inuabasi R. Kiseleva V. R. Muzykantov J. C. Mason G. M. Birdsey A. M. Randi
author_sort	C. Peghaire
title	The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
title_short	The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
title_full	The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
title_fullStr	The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
title_full_unstemmed	The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
title_sort	transcription factor erg regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c
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The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

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