Mechanisms of Resistance to Folate Pathway Inhibitors in <italic toggle="yes">Burkholderia pseudomallei</italic>: Deviation from the Norm

Mechanisms of Resistance to Folate Pathway Inhibitors in <italic toggle="yes">Burkholderia pseudomallei</italic>: Deviation from the Norm

ABSTRACT The trimethoprim and sulfamethoxazole combination, co-trimoxazole, plays a vital role in the treatment of Burkholderia pseudomallei infections. Previous studies demonstrated that the B. pseudomallei BpeEF-OprC efflux pump confers widespread trimethoprim resistance in clinical and environmen...

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Main Authors: Nicole L. Podnecky, Katherine A. Rhodes, Takehiko Mima, Heather R. Drew, Sunisa Chirakul, Vanaporn Wuthiekanun, James M. Schupp, Derek S. Sarovich, Bart J. Currie, Paul Keim, Herbert P. Schweizer
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
Burkholderia
antibiotic
drug resistance mechanisms
efflux pumps
melioidosis
Microbiology
QR1-502
Online Access:https://doaj.org/article/77994e52dbb14b41a3348e2f7e7f93ce
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