Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.

<h4>Background</h4>To investigate the association between XPD Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.<h4>Methods</h4>We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuan Yuan Hu, Hua Yuan, Guang Bing Jiang, Ning Chen, Li Wen, Wei Dong Leng, Xian Tao Zeng, Yu Ming Niu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/779cf7c30c9f46029b24489b2d1b5445
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:779cf7c30c9f46029b24489b2d1b5445
record_format	dspace
spelling	oai:doaj.org-article:779cf7c30c9f46029b24489b2d1b54452021-11-18T07:21:27ZAssociations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.1932-620310.1371/journal.pone.0035220https://doaj.org/article/779cf7c30c9f46029b24489b2d1b54452012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536360/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To investigate the association between XPD Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.<h4>Methods</h4>We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer and 4,452 controls. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between XPD Asp312Asn polymorphism and head and neck cancer risk.<h4>Results</h4>Overall, no significant association between XPD Asp312Asn polymorphism and head and neck cancer risk was found in this meta-analysis (Asn/Asn vs. Asp/Asp: OR = 0.95, 95%CI = 0.80-1.13, P = 0.550, P(heterogeneity) = 0.126; Asp/Asn vs. Asp/Asp: OR = 1.11, 95%CI = 0.99-1.24, P = 0.065, P(heterogeneity) = 0.663; Asn/Asn+Asp/Asn vs. Asp/Asp: OR = 1.07, 95%CI = 0.97-1.19, P = 0.189, P(heterogeneity) = 0.627; Asn/Asn vs. Asp/Asp+Asp/Asn: OR = 0.87, 95%CI = 0.68-1.10, P = 0.243, P(heterogeneity) = 0.089). In the subgroup analysis by HWE, ethnicity, and study design, there was still no significant association detected in all genetic models.<h4>Conclusions</h4>This meta-analysis demonstrates that XPD Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.Yuan Yuan HuHua YuanGuang Bing JiangNing ChenLi WenWei Dong LengXian Tao ZengYu Ming NiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35220 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan Yuan Hu Hua Yuan Guang Bing Jiang Ning Chen Li Wen Wei Dong Leng Xian Tao Zeng Yu Ming Niu Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
description	<h4>Background</h4>To investigate the association between XPD Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.<h4>Methods</h4>We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer and 4,452 controls. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between XPD Asp312Asn polymorphism and head and neck cancer risk.<h4>Results</h4>Overall, no significant association between XPD Asp312Asn polymorphism and head and neck cancer risk was found in this meta-analysis (Asn/Asn vs. Asp/Asp: OR = 0.95, 95%CI = 0.80-1.13, P = 0.550, P(heterogeneity) = 0.126; Asp/Asn vs. Asp/Asp: OR = 1.11, 95%CI = 0.99-1.24, P = 0.065, P(heterogeneity) = 0.663; Asn/Asn+Asp/Asn vs. Asp/Asp: OR = 1.07, 95%CI = 0.97-1.19, P = 0.189, P(heterogeneity) = 0.627; Asn/Asn vs. Asp/Asp+Asp/Asn: OR = 0.87, 95%CI = 0.68-1.10, P = 0.243, P(heterogeneity) = 0.089). In the subgroup analysis by HWE, ethnicity, and study design, there was still no significant association detected in all genetic models.<h4>Conclusions</h4>This meta-analysis demonstrates that XPD Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.
format	article
author	Yuan Yuan Hu Hua Yuan Guang Bing Jiang Ning Chen Li Wen Wei Dong Leng Xian Tao Zeng Yu Ming Niu
author_facet	Yuan Yuan Hu Hua Yuan Guang Bing Jiang Ning Chen Li Wen Wei Dong Leng Xian Tao Zeng Yu Ming Niu
author_sort	Yuan Yuan Hu
title	Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
title_short	Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
title_full	Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
title_fullStr	Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
title_full_unstemmed	Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
title_sort	associations between xpd asp312asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/779cf7c30c9f46029b24489b2d1b5445
work_keys_str_mv	AT yuanyuanhu associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT huayuan associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT guangbingjiang associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT ningchen associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT liwen associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT weidongleng associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT xiantaozeng associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects AT yumingniu associationsbetweenxpdasp312asnpolymorphismandriskofheadandneckcancerametaanalysisbasedon7122subjects
_version_	1718423606109667328

Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.

Ejemplares similares