Biological membrane lipids in norm and pathology (literature review)

This article discusses modern ideas about the structure of biological membranes, presents their basic physicochemical properties, and describes composition and structure of phospholipids from the chemical point of view. Plasmatic membrane has unique receptor-signaling functions regulating essential...

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Autores principales:	S. V. Mukhomedzyanova, Yu. I. Pivovarov, O. V. Bogdanova, L. A. Dmitrieva, A. A. Shulunov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	erythrocyte membrane phospholipids lipid bilayer Science Q
Acceso en línea:	https://doaj.org/article/779ddb65ca7b4801b6450e091f8e6af3
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spelling	oai:doaj.org-article:779ddb65ca7b4801b6450e091f8e6af32021-11-23T06:14:38ZBiological membrane lipids in norm and pathology (literature review)2541-94202587-959610.12737/article_59e8bcd3d6fcb1.49315019https://doaj.org/article/779ddb65ca7b4801b6450e091f8e6af32017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/431https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This article discusses modern ideas about the structure of biological membranes, presents their basic physicochemical properties, and describes composition and structure of phospholipids from the chemical point of view. Plasmatic membrane has unique receptor-signaling functions regulating essential cellular processes, damage to which can lead to cell death. The article introduces such features of membrane lipids and proteins as fluidity or ability to lateral shift, their permeability and phase conditions; describes the effects of cholesterol on phase transitions, fluidity, elasticity, permeability and mechanical strength of the bilayer. The paper discusses transmembrane or lateral asymmetry of lipid membranes, how it is supported, and what functions it has. Different configurations of hydrocarbon chains of fatty acids and their value are considered. Because the development of various pathological processes and conditions accompanied by molecular biological changes of cell membranes, it primarily concerns erythrocyte membrane, as they are composed of many easily-oxidized phospholipids and they come in contact with relatively high concentrations of oxygen, it is important to examine the role of erythrocyte lipid layer. The impact of various damaging factors on the tissues of cells and organs triggers the universal response as consequence of such molecular mechanisms as intensification of lipid peroxidation, activation of endogenous phospholipases and proteases, reduced activity of antioxidant defense system of the cell.S. V. MukhomedzyanovaYu. I. PivovarovO. V. BogdanovaL. A. DmitrievaA. A. ShulunovScientific Сentre for Family Health and Human Reproduction Problemsarticleerythrocytemembranephospholipidslipid bilayerScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 43-49 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	erythrocyte membrane phospholipids lipid bilayer Science Q
spellingShingle	erythrocyte membrane phospholipids lipid bilayer Science Q S. V. Mukhomedzyanova Yu. I. Pivovarov O. V. Bogdanova L. A. Dmitrieva A. A. Shulunov Biological membrane lipids in norm and pathology (literature review)
description	This article discusses modern ideas about the structure of biological membranes, presents their basic physicochemical properties, and describes composition and structure of phospholipids from the chemical point of view. Plasmatic membrane has unique receptor-signaling functions regulating essential cellular processes, damage to which can lead to cell death. The article introduces such features of membrane lipids and proteins as fluidity or ability to lateral shift, their permeability and phase conditions; describes the effects of cholesterol on phase transitions, fluidity, elasticity, permeability and mechanical strength of the bilayer. The paper discusses transmembrane or lateral asymmetry of lipid membranes, how it is supported, and what functions it has. Different configurations of hydrocarbon chains of fatty acids and their value are considered. Because the development of various pathological processes and conditions accompanied by molecular biological changes of cell membranes, it primarily concerns erythrocyte membrane, as they are composed of many easily-oxidized phospholipids and they come in contact with relatively high concentrations of oxygen, it is important to examine the role of erythrocyte lipid layer. The impact of various damaging factors on the tissues of cells and organs triggers the universal response as consequence of such molecular mechanisms as intensification of lipid peroxidation, activation of endogenous phospholipases and proteases, reduced activity of antioxidant defense system of the cell.
format	article
author	S. V. Mukhomedzyanova Yu. I. Pivovarov O. V. Bogdanova L. A. Dmitrieva A. A. Shulunov
author_facet	S. V. Mukhomedzyanova Yu. I. Pivovarov O. V. Bogdanova L. A. Dmitrieva A. A. Shulunov
author_sort	S. V. Mukhomedzyanova
title	Biological membrane lipids in norm and pathology (literature review)
title_short	Biological membrane lipids in norm and pathology (literature review)
title_full	Biological membrane lipids in norm and pathology (literature review)
title_fullStr	Biological membrane lipids in norm and pathology (literature review)
title_full_unstemmed	Biological membrane lipids in norm and pathology (literature review)
title_sort	biological membrane lipids in norm and pathology (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/779ddb65ca7b4801b6450e091f8e6af3
work_keys_str_mv	AT svmukhomedzyanova biologicalmembranelipidsinnormandpathologyliteraturereview AT yuipivovarov biologicalmembranelipidsinnormandpathologyliteraturereview AT ovbogdanova biologicalmembranelipidsinnormandpathologyliteraturereview AT ladmitrieva biologicalmembranelipidsinnormandpathologyliteraturereview AT aashulunov biologicalmembranelipidsinnormandpathologyliteraturereview
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Biological membrane lipids in norm and pathology (literature review)

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