Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study

Jianbo Lai,1–3,* Weihua Zhou,1–3,* Qiaoqiao Lu,1 Tingting Huang,1 Yi Xu,1–3 Shaohua Hu1–3 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2The Key Laboratory of Ment...

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Autores principales:	Lai JB, Zhou WH, Lu QQ, Huang TT, Xu Y, Hu SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Obsessive-compulsive disorder constipation laxative hospital stay paroxetine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/779e548c0b814ab1b7d93d7c05634ab2
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spelling	oai:doaj.org-article:779e548c0b814ab1b7d93d7c05634ab22021-12-02T05:52:39ZLaxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study1178-2021https://doaj.org/article/779e548c0b814ab1b7d93d7c05634ab22018-04-01T00:00:00Zhttps://www.dovepress.com/laxative-use-and-clinical-correlates-in-hospitalized-patients-with-obs-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jianbo Lai,1–3,* Weihua Zhou,1–3,* Qiaoqiao Lu,1 Tingting Huang,1 Yi Xu,1–3 Shaohua Hu1–3 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, People’s Republic of China; 3Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China *These authors contributed equally to this work Background: Constipation is a common clinical problem with insufficient attention. Medication-emergent constipation is a rarely studied adverse reaction in patients with obsessive-compulsive disorder (OCD).Methods: In this descriptive study, we retrospectively investigated the prevalence of laxative use and its relationship with clinical characteristics in hospitalized OCD patients. A total of 51 OCD patients were included in the final analysis.Results: The proportion of patients using laxatives was 31.4%, and the commonly used laxatives were phenolphthalein tablet, lactulose and congrongtongbian oral liquid (a patent herbal medicine). In the laxative group, hospital stays were longer when compared to the nonlaxative group. Moreover, the dose of paroxetine was higher in patients treated with laxatives than in those without laxative use. Correlation analysis indicated that laxative use was positively associated with hospital stays, as well as the dose of paroxetine.Conclusion: The current study provided a preliminary picture of constipation and laxative use in hospitalized OCD patients. Close monitoring and treatment of constipation are recommended in OCD patients with pharmacotherapy. Keywords: obsessive-compulsive disorder, constipation, laxative, hospital stay, paroxetineLai JBZhou WHLu QQHuang TTXu YHu SHDove Medical PressarticleObsessive-compulsive disorderconstipationlaxativehospital stayparoxetineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 933-936 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obsessive-compulsive disorder constipation laxative hospital stay paroxetine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Obsessive-compulsive disorder constipation laxative hospital stay paroxetine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lai JB Zhou WH Lu QQ Huang TT Xu Y Hu SH Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
description	Jianbo Lai,1–3,* Weihua Zhou,1–3,* Qiaoqiao Lu,1 Tingting Huang,1 Yi Xu,1–3 Shaohua Hu1–3 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, People’s Republic of China; 3Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China *These authors contributed equally to this work Background: Constipation is a common clinical problem with insufficient attention. Medication-emergent constipation is a rarely studied adverse reaction in patients with obsessive-compulsive disorder (OCD).Methods: In this descriptive study, we retrospectively investigated the prevalence of laxative use and its relationship with clinical characteristics in hospitalized OCD patients. A total of 51 OCD patients were included in the final analysis.Results: The proportion of patients using laxatives was 31.4%, and the commonly used laxatives were phenolphthalein tablet, lactulose and congrongtongbian oral liquid (a patent herbal medicine). In the laxative group, hospital stays were longer when compared to the nonlaxative group. Moreover, the dose of paroxetine was higher in patients treated with laxatives than in those without laxative use. Correlation analysis indicated that laxative use was positively associated with hospital stays, as well as the dose of paroxetine.Conclusion: The current study provided a preliminary picture of constipation and laxative use in hospitalized OCD patients. Close monitoring and treatment of constipation are recommended in OCD patients with pharmacotherapy. Keywords: obsessive-compulsive disorder, constipation, laxative, hospital stay, paroxetine
format	article
author	Lai JB Zhou WH Lu QQ Huang TT Xu Y Hu SH
author_facet	Lai JB Zhou WH Lu QQ Huang TT Xu Y Hu SH
author_sort	Lai JB
title	Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
title_short	Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
title_full	Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
title_fullStr	Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
title_full_unstemmed	Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
title_sort	laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/779e548c0b814ab1b7d93d7c05634ab2
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Laxative use and clinical correlates in hospitalized patients with obsessive-compulsive disorder: a retrospective descriptive study

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