Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.

<h4>Objective</h4>To assess sociodemographic, clinical and treatment factors as well as depression outcome in a large representative clinical sample of psychiatric depressive outpatients and to determine if melancholic and atypical depression can be differentiated from residual non-melan...

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Autores principales:	Margalida Gili, Miquel Roca, Silvia Armengol, David Asensio, Javier Garcia-Campayo, Gordon Parker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77a6cbd19ddc464e834026f7c4e4caa4
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spelling	oai:doaj.org-article:77a6cbd19ddc464e834026f7c4e4caa42021-11-18T08:10:51ZClinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.1932-620310.1371/journal.pone.0048200https://doaj.org/article/77a6cbd19ddc464e834026f7c4e4caa42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23110213/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To assess sociodemographic, clinical and treatment factors as well as depression outcome in a large representative clinical sample of psychiatric depressive outpatients and to determine if melancholic and atypical depression can be differentiated from residual non-melancholic depressive conditions.<h4>Subjects/materials and method</h4>A prospective, naturalistic, multicentre, nationwide epidemiological study of 1455 depressive outpatients was undertaken. Severity of depressive symptoms was assessed by the Hamilton Depression Rating Scale (HDRS) and the Self Rated Inventory of Depressive Symptomatology (IDS-SR(30)). IDS-SR(30) defines melancholic and atypical depression according to DSM-IV criteria. Assessments were carried out after 6-8 weeks of antidepressant treatment and after 14-20 weeks of continuation treatment.<h4>Results</h4>Melancholic patients (16.2%) were more severely depressed, had more depressive episodes and shorter episode duration than atypical (24.7%) and non-melancholic patients. Atypical depressive patients showed higher rates of co-morbid anxiety disorders and substance abuse. Melancholic patients showed lower rates of remission.<h4>Conclusion</h4>Our study supports a different clinical pattern and treatment outcome for melancholic and atypical depression subtypes.Margalida GiliMiquel RocaSilvia ArmengolDavid AsensioJavier Garcia-CampayoGordon ParkerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48200 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Margalida Gili Miquel Roca Silvia Armengol David Asensio Javier Garcia-Campayo Gordon Parker Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
description	<h4>Objective</h4>To assess sociodemographic, clinical and treatment factors as well as depression outcome in a large representative clinical sample of psychiatric depressive outpatients and to determine if melancholic and atypical depression can be differentiated from residual non-melancholic depressive conditions.<h4>Subjects/materials and method</h4>A prospective, naturalistic, multicentre, nationwide epidemiological study of 1455 depressive outpatients was undertaken. Severity of depressive symptoms was assessed by the Hamilton Depression Rating Scale (HDRS) and the Self Rated Inventory of Depressive Symptomatology (IDS-SR(30)). IDS-SR(30) defines melancholic and atypical depression according to DSM-IV criteria. Assessments were carried out after 6-8 weeks of antidepressant treatment and after 14-20 weeks of continuation treatment.<h4>Results</h4>Melancholic patients (16.2%) were more severely depressed, had more depressive episodes and shorter episode duration than atypical (24.7%) and non-melancholic patients. Atypical depressive patients showed higher rates of co-morbid anxiety disorders and substance abuse. Melancholic patients showed lower rates of remission.<h4>Conclusion</h4>Our study supports a different clinical pattern and treatment outcome for melancholic and atypical depression subtypes.
format	article
author	Margalida Gili Miquel Roca Silvia Armengol David Asensio Javier Garcia-Campayo Gordon Parker
author_facet	Margalida Gili Miquel Roca Silvia Armengol David Asensio Javier Garcia-Campayo Gordon Parker
author_sort	Margalida Gili
title	Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
title_short	Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
title_full	Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
title_fullStr	Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
title_full_unstemmed	Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
title_sort	clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/77a6cbd19ddc464e834026f7c4e4caa4
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Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.

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