Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Asmaa M Shehata,1 Fatma MS Salem,1 Eiman M El-Saied,1 Sahar S Abd El-Rahman,2 Mohamed Y Mahmoud,1 Peter A Noshy1 1Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt; 2Department of Pathology, Faculty of Veterinary Medicine, Cairo University,...

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Autores principales:	Shehata AM, Salem FMS, El-Saied EM, Abd El-Rahman SS, Mahmoud MY, Noshy PA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	antioxidants dna damage endocrinology oxidative stress sperm evaluation testes. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/77a8c36bb7864812833724a8d3b849a1
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spelling	oai:doaj.org-article:77a8c36bb7864812833724a8d3b849a12021-12-02T17:20:08ZZinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats1178-2013https://doaj.org/article/77a8c36bb7864812833724a8d3b849a12021-03-01T00:00:00Zhttps://www.dovepress.com/zinc-nanoparticles-ameliorate-the-reproductive-toxicity-induced-by-sil-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Asmaa M Shehata,1 Fatma MS Salem,1 Eiman M El-Saied,1 Sahar S Abd El-Rahman,2 Mohamed Y Mahmoud,1 Peter A Noshy1 1Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt; 2Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptCorrespondence: Peter A Noshy Email vet_peter@cu.edu.egIntroduction: Silver nanoparticles (Ag-NPs) are among the most commonly used nanoparticles in different fields. Zinc nanoparticles (Zn-NPs) are known for their antioxidant effect. This study was designed to investigate the adverse effects of Ag-NPs (50 nm) on the male reproductive system and also the ameliorative effect of Zn-NPs (100 nm) against these harmful effects.Methods: Forty adult male rats were used in this study; they were randomly divided into four equal groups: control group, Ag-NPs group, Zn-NPs group, Ag-NPs + Zn-NPs group. Ag-NPs (50 mg/kg) and/or Zn-NPs (30 mg/kg) were administered orally for 90 days.Results: The results revealed that exposure to Ag-NPs adversely affected sperm motility, morphology, viability, and concentration. Ag-NPs also induced oxidative stress and lipid peroxidation in testicular tissue. The exposure to Ag-NPs decreased serum FSH, LH, and testosterone hormones. Additionally, comet assay revealed DNA degeneration in the testicular tissue of rats exposed to Ag-NPs. Histopathological examination showed various histological alterations in the testes of rats intoxicated with Ag-NPs. Furthermore, co-administration of Zn-NPs ameliorated most of the toxic effects of Ag-NPs via their antioxidative capacity.Keywords: antioxidants, DNA damage, endocrinology, oxidative stress, sperm evaluation, testesShehata AMSalem FMSEl-Saied EMAbd El-Rahman SSMahmoud MYNoshy PADove Medical Pressarticleantioxidantsdna damageendocrinologyoxidative stresssperm evaluationtestes.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2555-2568 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidants dna damage endocrinology oxidative stress sperm evaluation testes. Medicine (General) R5-920
spellingShingle	antioxidants dna damage endocrinology oxidative stress sperm evaluation testes. Medicine (General) R5-920 Shehata AM Salem FMS El-Saied EM Abd El-Rahman SS Mahmoud MY Noshy PA Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats
description	Asmaa M Shehata,1 Fatma MS Salem,1 Eiman M El-Saied,1 Sahar S Abd El-Rahman,2 Mohamed Y Mahmoud,1 Peter A Noshy1 1Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt; 2Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptCorrespondence: Peter A Noshy Email vet_peter@cu.edu.egIntroduction: Silver nanoparticles (Ag-NPs) are among the most commonly used nanoparticles in different fields. Zinc nanoparticles (Zn-NPs) are known for their antioxidant effect. This study was designed to investigate the adverse effects of Ag-NPs (50 nm) on the male reproductive system and also the ameliorative effect of Zn-NPs (100 nm) against these harmful effects.Methods: Forty adult male rats were used in this study; they were randomly divided into four equal groups: control group, Ag-NPs group, Zn-NPs group, Ag-NPs + Zn-NPs group. Ag-NPs (50 mg/kg) and/or Zn-NPs (30 mg/kg) were administered orally for 90 days.Results: The results revealed that exposure to Ag-NPs adversely affected sperm motility, morphology, viability, and concentration. Ag-NPs also induced oxidative stress and lipid peroxidation in testicular tissue. The exposure to Ag-NPs decreased serum FSH, LH, and testosterone hormones. Additionally, comet assay revealed DNA degeneration in the testicular tissue of rats exposed to Ag-NPs. Histopathological examination showed various histological alterations in the testes of rats intoxicated with Ag-NPs. Furthermore, co-administration of Zn-NPs ameliorated most of the toxic effects of Ag-NPs via their antioxidative capacity.Keywords: antioxidants, DNA damage, endocrinology, oxidative stress, sperm evaluation, testes
format	article
author	Shehata AM Salem FMS El-Saied EM Abd El-Rahman SS Mahmoud MY Noshy PA
author_facet	Shehata AM Salem FMS El-Saied EM Abd El-Rahman SS Mahmoud MY Noshy PA
author_sort	Shehata AM
title	Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats
title_short	Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats
title_full	Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats
title_fullStr	Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats
title_full_unstemmed	Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats
title_sort	zinc nanoparticles ameliorate the reproductive toxicity induced by silver nanoparticles in male rats
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/77a8c36bb7864812833724a8d3b849a1
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Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

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