Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota

Abstract Diet is a key factor influencing gut microbiota (GM) composition and functions, which in turn affect host health. Among dietary regimens, time-restricted (TR) feeding has been associated to numerous health benefits. The impact of TR feeding on the GM composition has been mostly explored by...

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Autores principales:	Antonio Palomba, Alessandro Tanca, Marcello Abbondio, Rosangela Sau, Monica Serra, Fabio Marongiu, Cristina Fraumene, Daniela Pagnozzi, Ezio Laconi, Sergio Uzzau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/77a9e3c3799e4b0987048d81514ab9b6
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spelling	oai:doaj.org-article:77a9e3c3799e4b0987048d81514ab9b62021-12-05T12:17:08ZTime-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota10.1038/s41522-021-00256-x2055-5008https://doaj.org/article/77a9e3c3799e4b0987048d81514ab9b62021-12-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00256-xhttps://doaj.org/toc/2055-5008Abstract Diet is a key factor influencing gut microbiota (GM) composition and functions, which in turn affect host health. Among dietary regimens, time-restricted (TR) feeding has been associated to numerous health benefits. The impact of TR feeding on the GM composition has been mostly explored by means of metagenomic sequencing. To date, however, little is known about the modulation of GM functions by this dietary regimen. Here, we analyzed the effects of TR feeding on GM functions by evaluating protein expression changes in a rat model through a metaproteomic approach. We observed that TR feeding has a relevant impact on GM functions, specifically leading to an increased abundance of several enzymes involved in carbohydrate and protein metabolism and expressed by Lactobacillus spp. and Akkermansia muciniphila. Taken together, these results contribute to deepening our knowledge about the key relationship between diet, GM, and health.Antonio PalombaAlessandro TancaMarcello AbbondioRosangela SauMonica SerraFabio MarongiuCristina FraumeneDaniela PagnozziEzio LaconiSergio UzzauNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Antonio Palomba Alessandro Tanca Marcello Abbondio Rosangela Sau Monica Serra Fabio Marongiu Cristina Fraumene Daniela Pagnozzi Ezio Laconi Sergio Uzzau Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
description	Abstract Diet is a key factor influencing gut microbiota (GM) composition and functions, which in turn affect host health. Among dietary regimens, time-restricted (TR) feeding has been associated to numerous health benefits. The impact of TR feeding on the GM composition has been mostly explored by means of metagenomic sequencing. To date, however, little is known about the modulation of GM functions by this dietary regimen. Here, we analyzed the effects of TR feeding on GM functions by evaluating protein expression changes in a rat model through a metaproteomic approach. We observed that TR feeding has a relevant impact on GM functions, specifically leading to an increased abundance of several enzymes involved in carbohydrate and protein metabolism and expressed by Lactobacillus spp. and Akkermansia muciniphila. Taken together, these results contribute to deepening our knowledge about the key relationship between diet, GM, and health.
format	article
author	Antonio Palomba Alessandro Tanca Marcello Abbondio Rosangela Sau Monica Serra Fabio Marongiu Cristina Fraumene Daniela Pagnozzi Ezio Laconi Sergio Uzzau
author_facet	Antonio Palomba Alessandro Tanca Marcello Abbondio Rosangela Sau Monica Serra Fabio Marongiu Cristina Fraumene Daniela Pagnozzi Ezio Laconi Sergio Uzzau
author_sort	Antonio Palomba
title	Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
title_short	Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
title_full	Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
title_fullStr	Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
title_full_unstemmed	Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota
title_sort	time-restricted feeding induces lactobacillus- and akkermansia-specific functional changes in the rat fecal microbiota
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77a9e3c3799e4b0987048d81514ab9b6
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Time-restricted feeding induces Lactobacillus- and Akkermansia-specific functional changes in the rat fecal microbiota

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