Discovery of fungal surface NADases predominantly present in pathogenic species

Discovery of fungal surface NADases predominantly present in pathogenic species

Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.

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Detalles Bibliográficos
Autores principales: Øyvind Strømland, Juha P. Kallio, Annica Pschibul, Renate H. Skoge, Hulda M. Harðardóttir, Lars J. Sverkeli, Thorsten Heinekamp, Olaf Kniemeyer, Marie Migaud, Mikhail V. Makarov, Toni I. Gossmann, Axel A. Brakhage, Mathias Ziegler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/77abc3c958834cf7b997e668235e194c
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Descripción
Sumario:Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.

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