Discovery of fungal surface NADases predominantly present in pathogenic species

Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.

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Autores principales:	Øyvind Strømland, Juha P. Kallio, Annica Pschibul, Renate H. Skoge, Hulda M. Harðardóttir, Lars J. Sverkeli, Thorsten Heinekamp, Olaf Kniemeyer, Marie Migaud, Mikhail V. Makarov, Toni I. Gossmann, Axel A. Brakhage, Mathias Ziegler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77abc3c958834cf7b997e668235e194c
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spelling	oai:doaj.org-article:77abc3c958834cf7b997e668235e194c2021-12-02T15:52:21ZDiscovery of fungal surface NADases predominantly present in pathogenic species10.1038/s41467-021-21307-z2041-1723https://doaj.org/article/77abc3c958834cf7b997e668235e194c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21307-zhttps://doaj.org/toc/2041-1723Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.Øyvind StrømlandJuha P. KallioAnnica PschibulRenate H. SkogeHulda M. HarðardóttirLars J. SverkeliThorsten HeinekampOlaf KniemeyerMarie MigaudMikhail V. MakarovToni I. GossmannAxel A. BrakhageMathias ZieglerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Øyvind Strømland Juha P. Kallio Annica Pschibul Renate H. Skoge Hulda M. Harðardóttir Lars J. Sverkeli Thorsten Heinekamp Olaf Kniemeyer Marie Migaud Mikhail V. Makarov Toni I. Gossmann Axel A. Brakhage Mathias Ziegler Discovery of fungal surface NADases predominantly present in pathogenic species
description	Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.
format	article
author	Øyvind Strømland Juha P. Kallio Annica Pschibul Renate H. Skoge Hulda M. Harðardóttir Lars J. Sverkeli Thorsten Heinekamp Olaf Kniemeyer Marie Migaud Mikhail V. Makarov Toni I. Gossmann Axel A. Brakhage Mathias Ziegler
author_facet	Øyvind Strømland Juha P. Kallio Annica Pschibul Renate H. Skoge Hulda M. Harðardóttir Lars J. Sverkeli Thorsten Heinekamp Olaf Kniemeyer Marie Migaud Mikhail V. Makarov Toni I. Gossmann Axel A. Brakhage Mathias Ziegler
author_sort	Øyvind Strømland
title	Discovery of fungal surface NADases predominantly present in pathogenic species
title_short	Discovery of fungal surface NADases predominantly present in pathogenic species
title_full	Discovery of fungal surface NADases predominantly present in pathogenic species
title_fullStr	Discovery of fungal surface NADases predominantly present in pathogenic species
title_full_unstemmed	Discovery of fungal surface NADases predominantly present in pathogenic species
title_sort	discovery of fungal surface nadases predominantly present in pathogenic species
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77abc3c958834cf7b997e668235e194c
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Discovery of fungal surface NADases predominantly present in pathogenic species

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