Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells

Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells

Abstract We have determined the lipid, protein and miRNA composition of skeletal muscle (SkM)-released extracellular vesicles (ELVs) from Ob/ob (OB) vs wild-type (WT) mice. The results showed that atrophic insulin-resistant OB-SkM released less ELVs than WT-SkM, highlighted by a RAB35 decrease and a...

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Main Authors: Audrey Jalabert, Laura Reininger, Emmanuelle Berger, Yohann Coute, Emmanuelle Meugnier, Alexis Forterre, Elizabeth Errazuriz-Cerda, Alain Geloen, Myriam Aouadi, Karim Bouzakri, Jennifer Rieusset, Sophie Rome
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/77abc8f4de834fbea9f2c2609f364754
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https://doaj.org/article/77abc8f4de834fbea9f2c2609f364754

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