Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation

Bone serves as the support for body and provide attachment points for the muscles. The musculoskeletal system is the basis for the human body to complete exercise. Studies believe that bone is not only the basis for constructing structures, but also participates in the regulation of organs outside b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuxiang Du, Lingli Zhang, Zhikun Wang, Xuan Zhao, Jun Zou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bone secreted protein cross-organ regulation endocrine regulation exercise prescription mechanical stimulation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/77ac3ef404e44b42821a3ed6e923c2e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77ac3ef404e44b42821a3ed6e923c2e1
record_format	dspace
spelling	oai:doaj.org-article:77ac3ef404e44b42821a3ed6e923c2e12021-11-30T18:44:13ZEndocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation2296-634X10.3389/fcell.2021.778015https://doaj.org/article/77ac3ef404e44b42821a3ed6e923c2e12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.778015/fullhttps://doaj.org/toc/2296-634XBone serves as the support for body and provide attachment points for the muscles. The musculoskeletal system is the basis for the human body to complete exercise. Studies believe that bone is not only the basis for constructing structures, but also participates in the regulation of organs outside bone. The realization of this function is closely related to the protein secreted by bone. Whether bone can realize their positions in the human body is also related to their secretion. Bone-derived proteins provide a medium for the targeted regulation of bones on organs, making the role of bone in human body more profound and concrete. Mechanical stimulation effects the extra-skeletal organs by causing quantitative changes in bone-derived factors. When bone receives mechanical stimulation, the nichle of bone responds, and the secretion of various factors changes. However, whether the proteins secreted by bone can interfere with disease requires more research. In this review article, we will first introduce the important reasons and significance of the in-depth study on bone-derived secretory proteins, and summarize the locations, structures and functions of these proteins. These functions will not only focus on the bone metabolism process, but also be reflected in the cross-organ regulation. We specifically explain the role of typical bone-derived secretory factors such as osteocalcin (OCN), osteopontin (OPN), sclerostin (SOST) and fibroblast growth factor 23 (FGF23) in different organs and metabolic processes, then establishing the relationship between them and diseases. Finally, we will discuss whether exercise or mechanical stimulation can have a definite effect on bone-derived secretory factors. Understanding their important role in cross-organ regulation is of great significance for the treatment of diseases, especially for the elderly people with more than one basic disease.Yuxiang DuLingli ZhangZhikun WangXuan ZhaoJun ZouFrontiers Media S.A.articlebonesecreted proteincross-organ regulationendocrine regulationexercise prescriptionmechanical stimulationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone secreted protein cross-organ regulation endocrine regulation exercise prescription mechanical stimulation Biology (General) QH301-705.5
spellingShingle	bone secreted protein cross-organ regulation endocrine regulation exercise prescription mechanical stimulation Biology (General) QH301-705.5 Yuxiang Du Lingli Zhang Zhikun Wang Xuan Zhao Jun Zou Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation
description	Bone serves as the support for body and provide attachment points for the muscles. The musculoskeletal system is the basis for the human body to complete exercise. Studies believe that bone is not only the basis for constructing structures, but also participates in the regulation of organs outside bone. The realization of this function is closely related to the protein secreted by bone. Whether bone can realize their positions in the human body is also related to their secretion. Bone-derived proteins provide a medium for the targeted regulation of bones on organs, making the role of bone in human body more profound and concrete. Mechanical stimulation effects the extra-skeletal organs by causing quantitative changes in bone-derived factors. When bone receives mechanical stimulation, the nichle of bone responds, and the secretion of various factors changes. However, whether the proteins secreted by bone can interfere with disease requires more research. In this review article, we will first introduce the important reasons and significance of the in-depth study on bone-derived secretory proteins, and summarize the locations, structures and functions of these proteins. These functions will not only focus on the bone metabolism process, but also be reflected in the cross-organ regulation. We specifically explain the role of typical bone-derived secretory factors such as osteocalcin (OCN), osteopontin (OPN), sclerostin (SOST) and fibroblast growth factor 23 (FGF23) in different organs and metabolic processes, then establishing the relationship between them and diseases. Finally, we will discuss whether exercise or mechanical stimulation can have a definite effect on bone-derived secretory factors. Understanding their important role in cross-organ regulation is of great significance for the treatment of diseases, especially for the elderly people with more than one basic disease.
format	article
author	Yuxiang Du Lingli Zhang Zhikun Wang Xuan Zhao Jun Zou
author_facet	Yuxiang Du Lingli Zhang Zhikun Wang Xuan Zhao Jun Zou
author_sort	Yuxiang Du
title	Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation
title_short	Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation
title_full	Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation
title_fullStr	Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation
title_full_unstemmed	Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation
title_sort	endocrine regulation of extra-skeletal organs by bone-derived secreted protein and the effect of mechanical stimulation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/77ac3ef404e44b42821a3ed6e923c2e1
work_keys_str_mv	AT yuxiangdu endocrineregulationofextraskeletalorgansbybonederivedsecretedproteinandtheeffectofmechanicalstimulation AT linglizhang endocrineregulationofextraskeletalorgansbybonederivedsecretedproteinandtheeffectofmechanicalstimulation AT zhikunwang endocrineregulationofextraskeletalorgansbybonederivedsecretedproteinandtheeffectofmechanicalstimulation AT xuanzhao endocrineregulationofextraskeletalorgansbybonederivedsecretedproteinandtheeffectofmechanicalstimulation AT junzou endocrineregulationofextraskeletalorgansbybonederivedsecretedproteinandtheeffectofmechanicalstimulation
_version_	1718406332898344960

Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation

Ejemplares similares