Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness.

Helicase regulation involves modulation of unwinding speed to maintain coordination of DNA replication fork activities and is vital for replisome progression. Currently, mechanisms for helicase regulation that involve interactions with both DNA strands through a steric exclusion and wrapping (SEW) m...

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Bibliographic Details
Main Authors: Megan S Behrmann, Himasha M Perera, Joy M Hoang, Trisha A Venkat, Bryan J Visser, David Bates, Michael A Trakselis
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
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Online Access:https://doaj.org/article/77aee7d7231e48be89bb2d4a92f4466a
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