Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness.
Helicase regulation involves modulation of unwinding speed to maintain coordination of DNA replication fork activities and is vital for replisome progression. Currently, mechanisms for helicase regulation that involve interactions with both DNA strands through a steric exclusion and wrapping (SEW) m...
Saved in:
Main Authors: | Megan S Behrmann, Himasha M Perera, Joy M Hoang, Trisha A Venkat, Bryan J Visser, David Bates, Michael A Trakselis |
---|---|
Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/77aee7d7231e48be89bb2d4a92f4466a |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
by: Simonetta Andreazza, et al.
Published: (2019) -
The mechanism of DNA unwinding by the eukaryotic replicative helicase
by: Daniel R. Burnham, et al.
Published: (2019) -
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
by: Seetha V Balasingham, et al.
Published: (2012) -
In TFIIH, XPD helicase is exclusively devoted to DNA repair.
by: Jochen Kuper, et al.
Published: (2014) -
Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
by: Hazal B. Kose, et al.
Published: (2020)