Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report

BackgroundParathyroid carcinoma (PC) is an extremely rare malignancy, characterized by slow progression, frequent recurrences and difficult-to-control hypercalcemia which is typically the main contributor to the morbidity and mortality of these patients. Patients often undergo repeated surgical rese...

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Autores principales:	Heleen Bollen, Brigitte Decallonne, Sandra Nuyts
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	case report parathyroid carcinoma radiotherapy radiosensitivity symptomatic treatment hypercalcemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/77b0b4d333964a1eb691a35bb6778b7d
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spelling	oai:doaj.org-article:77b0b4d333964a1eb691a35bb6778b7d2021-12-01T01:59:17ZRadiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report2234-943X10.3389/fonc.2021.733772https://doaj.org/article/77b0b4d333964a1eb691a35bb6778b7d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.733772/fullhttps://doaj.org/toc/2234-943XBackgroundParathyroid carcinoma (PC) is an extremely rare malignancy, characterized by slow progression, frequent recurrences and difficult-to-control hypercalcemia which is typically the main contributor to the morbidity and mortality of these patients. Patients often undergo repeated surgical resections, whether or not in combination with adjuvant radiation treatment. The role of radiation therapy within the symptomatic treatment of PC currently remains unclear.Case descriptionWe describe a 30-year-old male patient with an inoperable local relapse of PC and secondary symptomatic hypercalcemia, maximally pharmacologically treated. After a local radiation treatment to a total dose of 70 Gray in 35 fractions serum calcium and parathyroid hormone (PTH) levels decreased, accompanied by improvement of the severe gastro-intestinal disturbances.ConclusionFor patients with inoperable symptomatic PC despite maximal medical treatment who are in a good overall condition, radiation treatment can be considered in well-defined cases to decrease symptoms and improve quality of life.Heleen BollenHeleen BollenBrigitte DecallonneSandra NuytsSandra NuytsFrontiers Media S.A.articlecase reportparathyroid carcinomaradiotherapyradiosensitivitysymptomatic treatmenthypercalcemiaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case report parathyroid carcinoma radiotherapy radiosensitivity symptomatic treatment hypercalcemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	case report parathyroid carcinoma radiotherapy radiosensitivity symptomatic treatment hypercalcemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Heleen Bollen Heleen Bollen Brigitte Decallonne Sandra Nuyts Sandra Nuyts Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
description	BackgroundParathyroid carcinoma (PC) is an extremely rare malignancy, characterized by slow progression, frequent recurrences and difficult-to-control hypercalcemia which is typically the main contributor to the morbidity and mortality of these patients. Patients often undergo repeated surgical resections, whether or not in combination with adjuvant radiation treatment. The role of radiation therapy within the symptomatic treatment of PC currently remains unclear.Case descriptionWe describe a 30-year-old male patient with an inoperable local relapse of PC and secondary symptomatic hypercalcemia, maximally pharmacologically treated. After a local radiation treatment to a total dose of 70 Gray in 35 fractions serum calcium and parathyroid hormone (PTH) levels decreased, accompanied by improvement of the severe gastro-intestinal disturbances.ConclusionFor patients with inoperable symptomatic PC despite maximal medical treatment who are in a good overall condition, radiation treatment can be considered in well-defined cases to decrease symptoms and improve quality of life.
format	article
author	Heleen Bollen Heleen Bollen Brigitte Decallonne Sandra Nuyts Sandra Nuyts
author_facet	Heleen Bollen Heleen Bollen Brigitte Decallonne Sandra Nuyts Sandra Nuyts
author_sort	Heleen Bollen
title	Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
title_short	Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
title_full	Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
title_fullStr	Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
title_full_unstemmed	Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
title_sort	radiation treatment for inoperable local relapse of parathyroid carcinoma with symptomatic hypercalcemia: a case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/77b0b4d333964a1eb691a35bb6778b7d
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Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report

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