High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeostasis after to gastric bypass surgery, and report...
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Nature Portfolio
2021
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oai:doaj.org-article:77b147ec15344c3cb4b79626a96517bd2021-12-05T12:22:17ZHigh-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control10.1038/s41467-021-27289-22041-1723https://doaj.org/article/77b147ec15344c3cb4b79626a96517bd2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27289-2https://doaj.org/toc/2041-1723Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeostasis after to gastric bypass surgery, and report that improved glycemia was mediated by the growth hormone receptor.Jonathan M. DreyfussYixing YuchiXuehong DongVissarion EfthymiouHui PanDonald C. SimonsonAshley VernonFlorencia HalperinPratik AryalAnish KonkarYinong SebastianBrandon W. HiggsJoseph GrimsbyCristina M. RondinoneSimon KasifBarbara B. KahnKathleen FosterRandy SeeleyAllison GoldfineVera DjordjilovićMary Elizabeth PattiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q |
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Science Q Jonathan M. Dreyfuss Yixing Yuchi Xuehong Dong Vissarion Efthymiou Hui Pan Donald C. Simonson Ashley Vernon Florencia Halperin Pratik Aryal Anish Konkar Yinong Sebastian Brandon W. Higgs Joseph Grimsby Cristina M. Rondinone Simon Kasif Barbara B. Kahn Kathleen Foster Randy Seeley Allison Goldfine Vera Djordjilović Mary Elizabeth Patti High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| description |
Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeostasis after to gastric bypass surgery, and report that improved glycemia was mediated by the growth hormone receptor. |
| format |
article |
| author |
Jonathan M. Dreyfuss Yixing Yuchi Xuehong Dong Vissarion Efthymiou Hui Pan Donald C. Simonson Ashley Vernon Florencia Halperin Pratik Aryal Anish Konkar Yinong Sebastian Brandon W. Higgs Joseph Grimsby Cristina M. Rondinone Simon Kasif Barbara B. Kahn Kathleen Foster Randy Seeley Allison Goldfine Vera Djordjilović Mary Elizabeth Patti |
| author_facet |
Jonathan M. Dreyfuss Yixing Yuchi Xuehong Dong Vissarion Efthymiou Hui Pan Donald C. Simonson Ashley Vernon Florencia Halperin Pratik Aryal Anish Konkar Yinong Sebastian Brandon W. Higgs Joseph Grimsby Cristina M. Rondinone Simon Kasif Barbara B. Kahn Kathleen Foster Randy Seeley Allison Goldfine Vera Djordjilović Mary Elizabeth Patti |
| author_sort |
Jonathan M. Dreyfuss |
| title |
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| title_short |
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| title_full |
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| title_fullStr |
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| title_full_unstemmed |
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| title_sort |
high-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/77b147ec15344c3cb4b79626a96517bd |
| work_keys_str_mv |
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